Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0STY9 (GCH1_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CPR_1096
OrganismClostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier289380 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043684

Sites

Metal binding761Zinc By similarity
Metal binding791Zinc By similarity
Metal binding1471Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0STY9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 4D914A0E040334E9

FASTA18521,139
        10         20         30         40         50         60 
MIDKDKIREG MKLILEAIGE DANREGLIET PDRIARMYEE IFSGIGMNAK EHLSKTFEVH 

        70         80         90        100        110        120 
SNDLVLEKDI TFYSMCEHHL VPFYGKVHIA YIPNGRVVGL SKLARCVEVY SKKPQLQERL 

       130        140        150        160        170        180 
TTEIADSIME YLDAQGVMVV VEGEHMCMTM RGVRKPGAKT VTTTYRGKFL EDESLKNDVF 


RMISM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000312 Genomic DNA. Translation: ABG87682.1.
RefSeqYP_698418.1. NC_008262.1.

3D structure databases

ProteinModelPortalQ0STY9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING289380.CPR_1096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG87682; ABG87682; CPR_1096.
GeneID4206100.
KEGGcpr:CPR_1096.
PATRIC19490483. VBICloPer122123_1072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAPIIGRAW.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycCPER289380:GI76-1112-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CLOPS
AccessionPrimary (citable) accession number: Q0STY9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways