Q0STX7 (Q0STX7_CLOPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase HAMAP MF_00230
Short name=NN:DBI PRT HAMAP MF_00230
EC=2.4.2.21 HAMAP MF_00230

Alternative name(s):
N(1)-alpha-phosphoribosyltransferase HAMAP MF_00230

Gene names

Name:	cobT HAMAP MF_00230
Ordered Locus Names:	CPR_1108

Organism

Clostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP] EMBL ABG87158.1

Taxonomic identifier

289380 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity. HAMAP MF_00230 SAAS SAAS003200
Catalytic activity	Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. HAMAP MF_00230 SAAS SAAS003200
Pathway	Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. HAMAP MF_00230 SAAS SAAS003200
Sequence similarities	Belongs to the CobT family. HAMAP MF_00230

Ontologies

Keywords
Biological process	Cobalamin biosynthesis HAMAP MF_00230 SAAS SAAS003200
Molecular function	Glycosyltransferase HAMAP MF_00230 SAAS SAAS003200 EMBL ABG87158.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW nucleoside biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cobalamin-transporting ATPase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	315	1	Proton acceptor By similarity HAMAP MF_00230

Sequences

	Sequence		Length	Mass (Da)
	Q0STX7 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 41CBAF701EDC3887	FASTA	361	38,838
	10 20 30 40 50 60 MLNEVLKGIQ GLDNDMILKA KNRVDSLAKP LGSLGKLEDI AIRLSGITGN MFNNIDKKCV 70 80 90 100 110 120 IIMSSDNGVE EEGVASAPQC LTLLQTKNFI KGINGVGTLA KTNGTDLIVF DVGINSDEVI 130 140 150 160 170 180 EGVIDRKISK GTKNIYKEPA MTYEEAKKSL EIGIEAVKIA KEKGYKILGV GEMGIGNTTT 190 200 210 220 230 240 SAAVLKALIG CETSKVVGKG GGINNASFEK KKIIVEEVVK KHNIDFDDPI DIISKVGGYD 250 260 270 280 290 300 IGAMAGVFLG AAFYRIPVVI DGFISVVAAL LANRLNPLVK EFCFTSHKSQ EIGYDLAIKE 310 320 330 340 350 360 LGLDPILDLN MRLGEGSGCP IAFSVINFAI SMMNNMATFE EVNIDNSYLE DVKDKECYVV L

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000312 Genomic DNA. Translation: ABG87158.1.
RefSeq	YP_698430.1. NC_008262.1.
3D structure databases
ProteinModelPortal	Q0STX7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0STX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4205195.
GenomeReviews	Gene locus CPR_1108 in contig CP000312_GR.
KEGG	cpr:CPR_1108.
PATRIC	19490507. VBICloPer122123_1084.
TIGR	CPR_1108.
Phylogenomic databases
eggNOG	COG2038.
HOGENOM	HBG634399.
OMA	FICSVAA.
ProtClustDB	PRK00105.
Family and domain databases
HAMAP	MF_00230. CobT. [Tree]
InterPro	IPR003200. Nict_dMeBzImd_PRibTrfase-like. IPR023195. Nict_dMeBzImd_PRibTrfase_N. IPR017846. Nict_dMeBzImd_PRibTrfase_pro. [Graphical view]
Gene3D	G3DSA:1.10.1610.10. Nict_dMeBzImd_PRibTrfase_N. 1 hit.
KO	K00768.
Pfam	PF02277. DBI_PRT. 1 hit. [Graphical view]
SUPFAM	SSF52733. NN:DBI_PRT. 1 hit.
TIGRFAMs	TIGR03160. CobT_DBIPRT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0STX7_CLOPS

Accession

Primary (citable) accession number: Q0STX7

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)