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Q0STE8

- XPT2_CLOPS

UniProt

Q0STE8 - XPT2_CLOPS

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Protein
Xanthine phosphoribosyltransferase 2
Gene
xpt2, CPR_1287
Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei27 – 271Xanthine By similarity
Binding sitei159 – 1591Xanthine By similarity

GO - Molecular functioni

  1. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. XMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-HAMAP
  3. xanthine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciCPER289380:GI76-1302-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferase 2 (EC:2.4.2.22)
Short name:
XPRTase 2
Gene namesi
Name:xpt2
Ordered Locus Names:CPR_1287
OrganismiClostridium perfringens (strain SM101 / Type A)
Taxonomic identifieri289380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001824: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Xanthine phosphoribosyltransferase 2UniRule annotation
PRO_0000339692Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi289380.CPR_1287.

Structurei

3D structure databases

ProteinModelPortaliQ0STE8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 13555-phospho-alpha-D-ribose 1-diphosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000036777.
KOiK03816.
OMAiMIAIINA.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0STE8-1 [UniParc]FASTAAdd to Basket

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MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ    50
IDKILTIEST GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY 100
SFTKKTIYNV VVDKKFIKPG EKILIVDDFL ANACAVFGLI DVVKQAGAEV 150
VGVGIVIEKG FQSGRAHLED KGIRVESLVT IDKIEDGEVY FK 192
Length:192
Mass (Da):21,796
Last modified:September 5, 2006 - v1
Checksum:iD4D00782DBBF1471
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86940.1.
RefSeqiYP_698609.1. NC_008262.1.

Genome annotation databases

EnsemblBacteriaiABG86940; ABG86940; CPR_1287.
GeneIDi4205542.
KEGGicpr:CPR_1287.
PATRICi19490869. VBICloPer122123_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86940.1 .
RefSeqi YP_698609.1. NC_008262.1.

3D structure databases

ProteinModelPortali Q0STE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289380.CPR_1287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG86940 ; ABG86940 ; CPR_1287 .
GeneIDi 4205542.
KEGGi cpr:CPR_1287.
PATRICi 19490869. VBICloPer122123_1265.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000036777.
KOi K03816.
OMAi MIAIINA.
OrthoDBi EOG6GTZNX.

Enzyme and pathway databases

UniPathwayi UPA00602 ; UER00658 .
BioCyci CPER289380:GI76-1302-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01184. XPRTase.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01744. XPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM101 / Type A.

Entry informationi

Entry nameiXPT2_CLOPS
AccessioniPrimary (citable) accession number: Q0STE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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