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Q0STE8

- XPT2_CLOPS

UniProt

Q0STE8 - XPT2_CLOPS

Protein

Xanthine phosphoribosyltransferase 2

Gene

xpt2

Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

    Catalytic activityi

    XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei27 – 271XanthineUniRule annotation
    Binding sitei159 – 1591XanthineUniRule annotation

    GO - Molecular functioni

    1. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
    2. xanthine metabolic process Source: InterPro
    3. XMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciCPER289380:GI76-1302-MONOMER.
    UniPathwayiUPA00602; UER00658.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine phosphoribosyltransferase 2UniRule annotation (EC:2.4.2.22UniRule annotation)
    Short name:
    XPRTase 2UniRule annotation
    Gene namesi
    Name:xpt2UniRule annotation
    Ordered Locus Names:CPR_1287
    OrganismiClostridium perfringens (strain SM101 / Type A)
    Taxonomic identifieri289380 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001824: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Xanthine phosphoribosyltransferase 2PRO_0000339692Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi289380.CPR_1287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0STE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 13555-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0503.
    HOGENOMiHOG000036777.
    KOiK03816.
    OMAiMIAIINA.
    OrthoDBiEOG6GTZNX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01184. XPRTase.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR010079. Xanthine_PRibTrfase.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01744. XPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0STE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ    50
    IDKILTIEST GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY 100
    SFTKKTIYNV VVDKKFIKPG EKILIVDDFL ANACAVFGLI DVVKQAGAEV 150
    VGVGIVIEKG FQSGRAHLED KGIRVESLVT IDKIEDGEVY FK 192
    Length:192
    Mass (Da):21,796
    Last modified:September 5, 2006 - v1
    Checksum:iD4D00782DBBF1471
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000312 Genomic DNA. Translation: ABG86940.1.
    RefSeqiYP_698609.1. NC_008262.1.

    Genome annotation databases

    EnsemblBacteriaiABG86940; ABG86940; CPR_1287.
    GeneIDi4205542.
    KEGGicpr:CPR_1287.
    PATRICi19490869. VBICloPer122123_1265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000312 Genomic DNA. Translation: ABG86940.1 .
    RefSeqi YP_698609.1. NC_008262.1.

    3D structure databases

    ProteinModelPortali Q0STE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 289380.CPR_1287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG86940 ; ABG86940 ; CPR_1287 .
    GeneIDi 4205542.
    KEGGi cpr:CPR_1287.
    PATRICi 19490869. VBICloPer122123_1265.

    Phylogenomic databases

    eggNOGi COG0503.
    HOGENOMi HOG000036777.
    KOi K03816.
    OMAi MIAIINA.
    OrthoDBi EOG6GTZNX.

    Enzyme and pathway databases

    UniPathwayi UPA00602 ; UER00658 .
    BioCyci CPER289380:GI76-1302-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01184. XPRTase.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR010079. Xanthine_PRibTrfase.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01744. XPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SM101 / Type A.

    Entry informationi

    Entry nameiXPT2_CLOPS
    AccessioniPrimary (citable) accession number: Q0STE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3