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Protein

Xanthine phosphoribosyltransferase 2

Gene

xpt2

Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase 2 (xpt2), Xanthine phosphoribosyltransferase 1 (xpt1)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei27XanthineUniRule annotation1
Binding sitei159XanthineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferase 2UniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTase 2UniRule annotation
Gene namesi
Name:xpt2UniRule annotation
Ordered Locus Names:CPR_1287
OrganismiClostridium perfringens (strain SM101 / Type A)
Taxonomic identifieri289380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001824 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003396921 – 192Xanthine phosphoribosyltransferase 2Add BLAST192

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0STE8
SMRiQ0STE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 1355-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036777
KOiK03816

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01184 XPRTase, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR010079 Xanthine_PRibTrfase
PANTHERiPTHR43864:SF1 PTHR43864:SF1, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01744 XPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q0STE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ
60 70 80 90 100
IDKILTIEST GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY
110 120 130 140 150
SFTKKTIYNV VVDKKFIKPG EKILIVDDFL ANACAVFGLI DVVKQAGAEV
160 170 180 190
VGVGIVIEKG FQSGRAHLED KGIRVESLVT IDKIEDGEVY FK
Length:192
Mass (Da):21,796
Last modified:September 5, 2006 - v1
Checksum:iD4D00782DBBF1471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000312 Genomic DNA Translation: ABG86940.1
RefSeqiWP_003465824.1, NC_008262.1

Genome annotation databases

EnsemblBacteriaiABG86940; ABG86940; CPR_1287
GeneIDi29571392
KEGGicpr:CPR_1287

Entry informationi

Entry nameiXPT2_CLOPS
AccessioniPrimary (citable) accession number: Q0STE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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