Q0STE8 (XPT2_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xanthine phosphoribosyltransferase 2
Short name=XPRTase 2
EC=2.4.2.22

Gene names

Name:	xpt2
Ordered Locus Names:	CPR_1287

Organism

Clostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

289380 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium perfringens

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity. HAMAP-Rule MF_01184
Catalytic activity	XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01184
Pathway	Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01184
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01184.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	XMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway purine ribonucleoside salvage Inferred from electronic annotation. Source: HAMAP xanthine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	xanthine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Xanthine phosphoribosyltransferase 2 HAMAP-Rule MF_01184		PRO_0000339692
Regions
	Region	131 – 135	5	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Sites
	Binding site	20	1	Xanthine; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	27	1	Xanthine By similarity
	Binding site	159	1	Xanthine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0STE8 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: D4D00782DBBF1471	FASTA	192	21,796
	10 20 30 40 50 60 MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ IDKILTIEST 70 80 90 100 110 120 GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY SFTKKTIYNV VVDKKFIKPG 130 140 150 160 170 180 EKILIVDDFL ANACAVFGLI DVVKQAGAEV VGVGIVIEKG FQSGRAHLED KGIRVESLVT 190 IDKIEDGEVY FK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SM101 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000312 Genomic DNA. Translation: ABG86940.1.
RefSeq	YP_698609.1. NC_008262.1.
3D structure databases
ProteinModelPortal	Q0STE8.
ModBase	Search...
Protein-protein interaction databases
STRING	289380.CPR_1287.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG86940; ABG86940; CPR_1287.
GeneID	4205542.
KEGG	cpr:CPR_1287.
PATRIC	19490869. VBICloPer122123_1265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HOG000036777.
KO	K03816.
OMA	MIAIINA.
ProtClustDB	PRK09219.
Enzyme and pathway databases
BioCyc	CPER289380:GI76-1426-MONOMER.
UniPathway	UPA00602; UER00658.
Family and domain databases
HAMAP	MF_01184. XPRTase.
InterPro	IPR000836. PRibTrfase_dom. IPR010079. Xanthine_PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01744. XPRTase. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XPT2_CLOPS

Accession

Primary (citable) accession number: Q0STE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program