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Q0STE8

- XPT2_CLOPS

UniProt

Q0STE8 - XPT2_CLOPS

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Protein

Xanthine phosphoribosyltransferase 2

Gene

xpt2

Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei27 – 271XanthineUniRule annotation
Binding sitei159 – 1591XanthineUniRule annotation

GO - Molecular functioni

  1. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
  2. xanthine metabolic process Source: InterPro
  3. XMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciCPER289380:GI76-1302-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferase 2UniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTase 2UniRule annotation
Gene namesi
Name:xpt2UniRule annotation
Ordered Locus Names:CPR_1287
OrganismiClostridium perfringens (strain SM101 / Type A)
Taxonomic identifieri289380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001824: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Xanthine phosphoribosyltransferase 2PRO_0000339692Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi289380.CPR_1287.

Structurei

3D structure databases

ProteinModelPortaliQ0STE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 13555-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000036777.
KOiK03816.
OMAiMIAIINA.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0STE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ
60 70 80 90 100
IDKILTIEST GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY
110 120 130 140 150
SFTKKTIYNV VVDKKFIKPG EKILIVDDFL ANACAVFGLI DVVKQAGAEV
160 170 180 190
VGVGIVIEKG FQSGRAHLED KGIRVESLVT IDKIEDGEVY FK
Length:192
Mass (Da):21,796
Last modified:September 5, 2006 - v1
Checksum:iD4D00782DBBF1471
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86940.1.
RefSeqiYP_698609.1. NC_008262.1.

Genome annotation databases

EnsemblBacteriaiABG86940; ABG86940; CPR_1287.
GeneIDi4205542.
KEGGicpr:CPR_1287.
PATRICi19490869. VBICloPer122123_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86940.1 .
RefSeqi YP_698609.1. NC_008262.1.

3D structure databases

ProteinModelPortali Q0STE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289380.CPR_1287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG86940 ; ABG86940 ; CPR_1287 .
GeneIDi 4205542.
KEGGi cpr:CPR_1287.
PATRICi 19490869. VBICloPer122123_1265.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000036777.
KOi K03816.
OMAi MIAIINA.
OrthoDBi EOG6GTZNX.

Enzyme and pathway databases

UniPathwayi UPA00602 ; UER00658 .
BioCyci CPER289380:GI76-1302-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01184. XPRTase.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01744. XPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM101 / Type A.

Entry informationi

Entry nameiXPT2_CLOPS
AccessioniPrimary (citable) accession number: Q0STE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3