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Q0STE8 (XPT2_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xanthine phosphoribosyltransferase 2

Short name=XPRTase 2
EC=2.4.2.22
Gene names
Name:xpt2
Ordered Locus Names:CPR_1287
OrganismClostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier289380 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity. HAMAP-Rule MF_01184

Catalytic activity

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01184

Pathway

Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01184

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01184

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01184.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processXMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xanthine metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 192192Xanthine phosphoribosyltransferase 2 HAMAP-Rule MF_01184
PRO_0000339692

Regions

Region131 – 13555-phospho-alpha-D-ribose 1-diphosphate binding By similarity

Sites

Binding site201Xanthine; via amide nitrogen and carbonyl oxygen By similarity
Binding site271Xanthine By similarity
Binding site1591Xanthine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0STE8 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: D4D00782DBBF1471

FASTA19221,796
        10         20         30         40         50         60 
MELLKDKIKK EGRVTEDNIL MVDSFLNHQM DVEFFNEVGK EFKDRFKNDQ IDKILTIEST 

        70         80         90        100        110        120 
GIGLGIITAQ YFDNVPVVFG KKIERLPRNK REEVFNSEVY SFTKKTIYNV VVDKKFIKPG 

       130        140        150        160        170        180 
EKILIVDDFL ANACAVFGLI DVVKQAGAEV VGVGIVIEKG FQSGRAHLED KGIRVESLVT 

       190 
IDKIEDGEVY FK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000312 Genomic DNA. Translation: ABG86940.1.
RefSeqYP_698609.1. NC_008262.1.

3D structure databases

ProteinModelPortalQ0STE8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING289380.CPR_1287.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG86940; ABG86940; CPR_1287.
GeneID4205542.
KEGGcpr:CPR_1287.
PATRIC19490869. VBICloPer122123_1265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
HOGENOMHOG000036777.
KOK03816.
OMAMIAIINA.
OrthoDBEOG6GTZNX.

Enzyme and pathway databases

BioCycCPER289380:GI76-1302-MONOMER.
UniPathwayUPA00602; UER00658.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01184. XPRTase.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01744. XPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameXPT2_CLOPS
AccessionPrimary (citable) accession number: Q0STE8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways