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Q0STA0

- THIM_CLOPS

UniProt

Q0STA0 - THIM_CLOPS

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361Substrate; via amide nitrogenUniRule annotation
    Binding sitei112 – 1121ATPUniRule annotation
    Binding sitei160 – 1601ATPUniRule annotation
    Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPER289380:GI76-1350-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:CPR_1337
    OrganismiClostridium perfringens (strain SM101 / Type A)
    Taxonomic identifieri289380 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001824: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Hydroxyethylthiazole kinasePRO_1000021506Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi289380.CPR_1337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0STA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiAKPIMAE.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0STA0-1 [UniParc]FASTAAdd to Basket

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    MEVLKRENPL IHMITNYVTV NDLAQVTINY GGLPLMATHH DELKVITKMA    50
    NGLLVNIGTL EPYQMESSMI SMKIAKEKGI PSVLDSVCVQ VSKLRRDFAK 100
    KIILEGEPSL IKGNLAEIKT LIGETSNSIG IDSFEDSLSE NTKNKIKEYA 150
    KERNLIVVVS GVVDFITNGE ESASVKNGTY KMSKITGTGC MLGALLTLAL 200
    SFYDHKDLRF KEVVKAVSTW GICGELAEER LREKEGLMTF KYNLLDELSI 250
    INDEIIKERE KVIYE 265
    Length:265
    Mass (Da):29,595
    Last modified:September 5, 2006 - v1
    Checksum:iC60CCC5533A51D02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000312 Genomic DNA. Translation: ABG86073.1.
    RefSeqiYP_698657.1. NC_008262.1.

    Genome annotation databases

    EnsemblBacteriaiABG86073; ABG86073; CPR_1337.
    GeneIDi4205487.
    KEGGicpr:CPR_1337.
    PATRICi19490965. VBICloPer122123_1313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000312 Genomic DNA. Translation: ABG86073.1 .
    RefSeqi YP_698657.1. NC_008262.1.

    3D structure databases

    ProteinModelPortali Q0STA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 289380.CPR_1337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG86073 ; ABG86073 ; CPR_1337 .
    GeneIDi 4205487.
    KEGGi cpr:CPR_1337.
    PATRICi 19490965. VBICloPer122123_1313.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi AKPIMAE.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci CPER289380:GI76-1350-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SM101 / Type A.

    Entry informationi

    Entry nameiTHIM_CLOPS
    AccessioniPrimary (citable) accession number: Q0STA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3