Reviewed, UniProtKB/Swiss-Prot Q0ST92 (GAL1_CLOPS)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	CPR_1345

Organism

Clostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

289380 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Galactokinase HAMAP MF_00246		PRO_1000005747
Regions
	Nucleotide binding	122 – 132	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0ST92-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 66EC7346C40BE990	FASTA	387	43,060
	10 20 30 40 50 60 MELNTLKSTF INNFGKEPNS LFFSPGRINL IGEHIDYNGG FVFPCPITLG TFAAATLRDD 70 80 90 100 110 120 RICRAYSLNF ESLGVIEFSL DDLSYKKEDN WTNYLKGVLK VLIEKGYKID KGIDLVINGN 130 140 150 160 170 180 LPNGAGLSSS ASLEMLIVKI LDTFFSLNIS KVDAALIGKE VENTYIGVNS GIMDQFAISL 190 200 210 220 230 240 GEKDKAILLD CNSLYYEYVP LNLGDNSIII MNTNKRRELA DSKYNERRKE CDDSLDTLKK 250 260 270 280 290 300 YTNISSLCEL TSLEFETYKD KIEDSNKLRR CVHAISENER VKDAVKALKE NNLELFGQLM 310 320 330 340 350 360 NQSHISLRDD YEVTGKELDT LAENAWKQPG VLGARMTGAG FGGCAIAIVN NNHVDEFIKN 370 380 VGQAYKDAIG YEASFYVASI GNGPTEL

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000312 Genomic DNA. Translation: ABG87750.1.
RefSeq	YP_698665.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4206052.
GenomeReviews	Gene locus CPR_1345 in contig CP000312_GR.
KEGG	cpr:CPR_1345.
TIGR	CPR_1345.
Phylogenomic databases
HOGENOM	Q0ST92.
OMA	Q0ST92. YNDGFVM.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_CLOPS

Accession

Primary (citable) accession number: Q0ST92

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)