ID   URK_CLOPS               Reviewed;         208 AA.
AC   Q0SS52;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Uridine kinase;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase;
DE   AltName: Full=Cytidine monophosphokinase;
GN   Name=udk; OrderedLocusNames=CPR_1740;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R.,
RA   DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C.,
RA   Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J.,
RA   Sullivan S.A., Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S.,
RA   Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H.,
RA   Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I.,
RA   Melville S.B., Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial
RT   pathogen, Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; CP000312; ABG85407.1; -; Genomic_DNA.
DR   RefSeq; YP_699055.1; -.
DR   GeneID; 4204462; -.
DR   GenomeReviews; CP000312_GR; CPR_1740.
DR   KEGG; cpr:CPR_1740; -.
DR   TIGR; CPR_1740; -.
DR   HOGENOM; Q0SS52; -.
DR   OMA; Q0SS52; NQFIEPT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:HAMAP.
DR   GO; GO:0008655; P:pyrimidine salvage; IEA:HAMAP.
DR   HAMAP; MF_00551; -; 1.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    208       Uridine kinase.
FT                                /FTId=PRO_1000017872.
FT   NP_BIND      11     18       ATP (Potential).
SQ   SEQUENCE   208 AA;  23882 MW;  DF1AB1B674A6B929 CRC64;
     MKRPIFIGIT GGTGSGKSTI AKEIYRQFGE ECIAMIEQDS YYKDQSHLSM DDRVKTNYDH
     PNAFDNNLLV SHLESLLNGH CIQKPSYDFS IHNRIEDTTK VEPKEIVIVE GILILEDPRI
     RELLDIKIYV DTDADVRIIR RMVRDINERG RTIESVINQY LNVVKPMHNQ FTEPTKKFAD
     IIIPEGGHNK VAIDIIVAKI KEVLGKYE
//