Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0SS07 (NADK_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:CPR_1785
OrganismClostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier289380 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276NAD kinase HAMAP-Rule MF_00361
PRO_1000005404

Regions

Nucleotide binding61 – 622NAD By similarity
Nucleotide binding134 – 1352NAD By similarity
Nucleotide binding175 – 1806NAD By similarity

Sites

Active site611Proton acceptor By similarity
Binding site1451NAD By similarity
Binding site1621NAD By similarity
Binding site1641NAD By similarity
Binding site1721NAD; via carbonyl oxygen By similarity
Binding site2341NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0SS07 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: FFA5B323A2B500BB

FASTA27630,947
        10         20         30         40         50         60 
MRNIGIIINK EKDKENKILN LVILKVKEYL NPDEIKVIDQ FYKGDYKDLM SLDLLIVLGG 

        70         80         90        100        110        120 
DGTLLGVARK FSTVIDTPIL GINIGNLGFL VTAEISELDE ALYRIKVGDY KVEERMLLSC 

       130        140        150        160        170        180 
TIEGVTCSDE RALNDIVVAR GTLSRMAQYE VFINDELYAT FKGDGVIIST PVGSTAYSFS 

       190        200        210        220        230        240 
AGGPLIMPNL QIVSIVPICP HTPNSRPMII DGNNKVRVKP LINESDVFVT IDGQKALKLE 

       250        260        270 
KHNEVLIKKA KEFFRIISFD NKSYFKVLRK KLFKIE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000312 Genomic DNA. Translation: ABG87596.1.
RefSeqYP_699100.1. NC_008262.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING289380.CPR_1785.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG87596; ABG87596; CPR_1785.
GeneID4206209.
KEGGcpr:CPR_1785.
PATRIC19491873. VBICloPer122123_1765.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMARWEALCL.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycCPER289380:GI76-1796-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_CLOPS
AccessionPrimary (citable) accession number: Q0SS07
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families