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Q0SS05 (DXS_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:CPR_1787
OrganismClostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier289380 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6196191-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256402

Sequences

Sequence LengthMass (Da)Tools
Q0SS05 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 7721F2C2187C9BFA

FASTA61968,483
        10         20         30         40         50         60 
MSEILQKITD PKEIKDLDEK ELEMLAKELR EFLIESVSNT GGHFASNLGV IDLTVALFKN 

        70         80         90        100        110        120 
FDFSENRIIW DVGHQSYAYK ILTGRKDKFN TLRQYGGLCG FPKRTESEYD FFATGHSSTS 

       130        140        150        160        170        180 
LSSAAGMARA QKILGKDNKV IAVIGDGALT GGMALEALND IGYRKDNLII ILNDNQMSIC 

       190        200        210        220        230        240 
KNVGGLATYL NKLRMGVGYN KLKSDIGSTL DTTSLGKRVK NSLSKLKDGI KKIVVPSMYF 

       250        260        270        280        290        300 
EDIGLKYFGI VDGHNIRELN EVLSIAKSIK GPVIIHTVTK KGKGYELAEK NPNKYHGVSP 

       310        320        330        340        350        360 
FDLGEGVISK FANRNYSSTF GEEMIKLAKN DDKVVAITAA MPDGTGLKDF REEFPDRFFD 

       370        380        390        400        410        420 
VGIAEQHAVT LAAGMAAEGL KPFFAVYSTF LQRAYDQVLH DVCIQNLPVT LCLDRAGLVG 

       430        440        450        460        470        480 
EDGETHQGIF DISFLSPMPN MTIVAPKCID EMEVILKWAS NFNAPLAIRY PRGGDIDVNL 

       490        500        510        520        530        540 
KPLSKIEYGK WEKVQEGEKI AIVATGKMVQ HAMIAAQKIK EEKNIDILII NATFIKPIDK 

       550        560        570        580        590        600 
ELLNSLSKDG FKIVTIEDNI KKGGFGEGVL EYLNEIGHEE KIVTLAFNDK FIEHGKPDIL 

       610 
YRINGLDAEG IKNTLIELL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000312 Genomic DNA. Translation: ABG86715.1.
RefSeqYP_699102.1. NC_008262.1.

3D structure databases

ProteinModelPortalQ0SS05.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SS05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4205334.
GenomeReviewsGene locus CPR_1787 in contig CP000312_GR.
KEGGcpr:CPR_1787.
PATRIC19491877. VBICloPer122123_1767.
TIGRCPR_1787.

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAEDGRTHH.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycCPER289380:CPR_1787-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_CLOPS
AccessionPrimary (citable) accession number: Q0SS05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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