Q0SRU6 (MUTS2_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MutS2 protein

Gene names

Name:	mutS2
Ordered Locus Names:	CPR_1847

Organism

Clostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

289380 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium perfringens

Protein attributes

Sequence length	786 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the DNA mismatch repair MutS family. Contains 1 Smr domain.

Ontologies

Keywords
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	maintenance of fidelity involved in DNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 786	786	MutS2 protein HAMAP-Rule MF_00092		PRO_1000093355
Regions
	Domain	711 – 786	76	Smr
	Nucleotide binding	332 – 339	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0SRU6 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: E10FB60DBDE62AC0	FASTA	786	88,103
	10 20 30 40 50 60 MNDRVLRVLE FNKIKELVKG YAITKSAKEM VLDLKPYDSV YDVKEHLEET KEALDILMRK 70 80 90 100 110 120 GNPPFEGLYD VKEAITRAEK GGVLSIEGLL RIGNMLSVTR KLSDFLARKE EEEEHRILEG 130 140 150 160 170 180 MREGLIVLRG VESAISKAIV SEDEIADSAS DKLYSIRRSL KEKNSSIRDK VNSIVRSNAQ 190 200 210 220 230 240 YLQDSLYTVR GDRYVIPVKA EYKSQVPGLV HDQSSTGATL FIEPTALVNL NNEIKELMLK 250 260 270 280 290 300 ERAEIERILA ELSALVYKNI DVIKVNFNII VELDFIFAKA KYGSDLGGTM PIVNEEGVID 310 320 330 340 350 360 LMDARHPLIP KDKVVSSDIY LGREFSTLLI TGPNTGGKTV TLKTTGLIEL MGLSGLLIPA 370 380 390 400 410 420 SENSSISFFE EIFADIGDEQ SIEQSLSTFS SHMTNIVKIM EKANNKSFVL FDELGAGTDP 430 440 450 460 470 480 TEGAALAISI LENLRARGCR IMSTTHYSEL KGYALKTENV ENASVEFNVE TLRPTYRLLI 490 500 510 520 530 540 GVPGKSNAFE ISRRLGLKDN IIEEAKKVIS TESLQFEDLI QSLQEKSIKA ENDAREAAIL 550 560 570 580 590 600 RNDAEKYKNR YKEKFERIES VRDNVYADAR REAKQILDSA KEEADTILKN MRDLERMGIS 610 620 630 640 650 660 SDARRKLEAE RGKLRDKISD AEARLQKKKE EQKGEELKKI EVGMEALLPS INQKVIVLSK 670 680 690 700 710 720 PDNKGEVQVQ AGIMKINVKA KDLRVAKETK EEKKIKKREA RLNLRQVDPS IDLRGMDSEE 730 740 750 760 770 780 ACYTADKYLD DAYVAGRGEV TLVHGKGTGV LRKAINDMLK KHPHVKSHRL GEYGEGGTGV TVVILK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SM101 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000312 Genomic DNA. Translation: ABG87167.1.
RefSeq	YP_699161.1. NC_008262.1.
3D structure databases
ProteinModelPortal	Q0SRU6.
ModBase	Search...
Protein-protein interaction databases
STRING	289380.CPR_1847.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG87167; ABG87167; CPR_1847.
GeneID	4205204.
KEGG	cpr:CPR_1847.
PATRIC	19491997. VBICloPer122123_1826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1193.
HOGENOM	HOG000135096.
KO	K07456.
OMA	HDQSSTG.
ProtClustDB	PRK00409.
Enzyme and pathway databases
BioCyc	CPER289380:GI76-1980-MONOMER.
Family and domain databases
HAMAP	MF_00092. MutS2.
InterPro	IPR005747. DNA_mismatch_repair_MutS-2. IPR000432. DNA_mismatch_repair_MutS_C. IPR007696. DNA_mismatch_repair_MutS_core. IPR002625. Smr/MutS2_C. [Graphical view]
PANTHER	PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfam	PF00488. MutS_V. 1 hit. PF01713. Smr. 1 hit. [Graphical view]
PIRSF	PIRSF005814. MutS_YshD. 1 hit.
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01069. mutS2. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. PS50828. SMR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS2_CLOPS

Accession

Primary (citable) accession number: Q0SRU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program