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Q0SQ82

- FTHS_CLOPS

UniProt

Q0SQ82 - FTHS_CLOPS

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, CPR_2471
Organism
Clostridium perfringens (strain SM101 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER289380:GI76-2488-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:CPR_2471
OrganismiClostridium perfringens (strain SM101 / Type A)
Taxonomic identifieri289380 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001824: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300521Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi289380.CPR_2471.

Structurei

3D structure databases

ProteinModelPortaliQ0SQ82.
SMRiQ0SQ82. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0SQ82-1 [UniParc]FASTAAdd to Basket

« Hide

MKNDIEIAQS AKMEPIINIA KKIGLEEDDI ELYGKYKCKI SLDVIKRLEN    50
NKDGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNKIGKNTV IALREPSLGP 100
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL CAAIDNHIHQ 150
GNLLRIDSRR IVFKRVMDMN DRALRNIVVG MGGKINGFLR EDGFMITVAS 200
EIMAILCMAS DLEDLKERMG NILIAYNLDG EPVYAKELEI EGAMALLMKD 250
AIKPNLVQTL ENTPAIIHGG PFANIAHGCN SIIATKTALK MSDITITEAG 300
FGADLGAEKF LDIKCRYGNL NPDCVVLVAT IRALKHHGGV KKDELNISNV 350
DALNKGMKNL EKQIENIKAY GVPVVVAINK FITDSDEEVK AIEDFCKNIG 400
VEVSLTEVWE KGGEGGIDLA NKVIKTMENE PSNFKMIYDS EESIKDKILK 450
IVQTIYGGKG VNYTPQALKQ IAEIEKFNLD KLPICMAKTQ YSLSDNPSLL 500
GRPENFDITI KEVRVSNGAG FIVVLTGDVM TMPGLPKVPA ANRMDIKDNG 550
EIVGLF 556
Length:556
Mass (Da):60,423
Last modified:September 5, 2006 - v1
Checksum:i43442CB374610ED7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86014.1.
RefSeqiWP_011593175.1. NC_008262.1.
YP_699725.1. NC_008262.1.

Genome annotation databases

EnsemblBacteriaiABG86014; ABG86014; CPR_2471.
GeneIDi4205408.
KEGGicpr:CPR_2471.
PATRICi19493262. VBICloPer122123_2398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000312 Genomic DNA. Translation: ABG86014.1 .
RefSeqi WP_011593175.1. NC_008262.1.
YP_699725.1. NC_008262.1.

3D structure databases

ProteinModelPortali Q0SQ82.
SMRi Q0SQ82. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 289380.CPR_2471.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG86014 ; ABG86014 ; CPR_2471 .
GeneIDi 4205408.
KEGGi cpr:CPR_2471.
PATRICi 19493262. VBICloPer122123_2398.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPER289380:GI76-2488-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM101 / Type A.

Entry informationi

Entry nameiFTHS_CLOPS
AccessioniPrimary (citable) accession number: Q0SQ82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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