ID   ADD_CLOPS               Reviewed;         332 AA.
AC   Q0SQ45;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add; OrderedLocusNames=CPR_2515;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R.,
RA   DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C.,
RA   Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J.,
RA   Sullivan S.A., Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S.,
RA   Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H.,
RA   Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I.,
RA   Melville S.B., Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial
RT   pathogen, Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
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DR   EMBL; CP000312; ABG85954.1; -; Genomic_DNA.
DR   RefSeq; YP_699762.1; -.
DR   GeneID; 4205270; -.
DR   GenomeReviews; CP000312_GR; CPR_2515.
DR   KEGG; cpr:CPR_2515; -.
DR   TIGR; CPR_2515; -.
DR   HOGENOM; Q0SQ45; -.
DR   OMA; Q0SQ45; GQNVYDA.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:HAMAP.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynt...; IEA:HAMAP.
DR   HAMAP; MF_00540; -; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006330; A_deaminase.
DR   PANTHER; PTHR11409; A/AMP_deaminase; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
DR   PROSITE; PS00485; A_DEAMINASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Nucleotide metabolism.
FT   CHAIN         1    332       Adenosine deaminase.
FT                                /FTId=PRO_1000017658.
FT   ACT_SITE    197    197       Potential.
FT   ACT_SITE    245    245       Potential.
FT   ACT_SITE    278    278       Potential.
FT   ACT_SITE    279    279       Potential.
SQ   SEQUENCE   332 AA;  38086 MW;  0AD78DDAEA6D6CF3 CRC64;
     MNLLNLPKIE LHCHLDGSLR VETAIELAKK EGIKLHSYEY DKVKELLVIS KECNSLEDYL
     NRFALPAKLL QRPENLERVA FELMEDASKE NVKYIEIRFA PLLHLEKGMT QKEVIESVIK
     GIRKAEEFYD IKGNLILSCL RHHSIDSVYE VIEEGKNFIG KGVVAIDLAG GELEGFVKPY
     KEVMKLARES GFRVTIHAGE TGYGKNVRDA IELLGAERIG HGLFIFNDEE AYNLVKEKGV
     TLEMCPKSNI DTKGVNKYEE HPIYKYHKDN IRVNLSTDNR TVSNINLTEE FENVHKTFNI
     DFEDYKKIYL NSVEASFCSE ELKEKLKLSI II
//