ID   URK_BORAP               Reviewed;         207 AA.
AC   Q0SPE9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Uridine kinase;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase;
DE   AltName: Full=Cytidine monophosphokinase;
GN   Name=udk; OrderedLocusNames=BAPKO_0014;
OS   Borrelia afzelii (strain PKo).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M.,
RA   Suehnel J., Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; CP000395; ABH01279.1; -; Genomic_DNA.
DR   RefSeq; YP_709455.1; -.
DR   GeneID; 4227180; -.
DR   GenomeReviews; CP000395_GR; BAPKO_0014.
DR   KEGG; baf:BAPKO_0014; -.
DR   NMPDR; fig|390236.5.peg.82; -.
DR   HOGENOM; Q0SPE9; -.
DR   OMA; Q0SPE9; NQFIEPT.
DR   BioCyc; BAFZ390236:BAPKO_0014-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:HAMAP.
DR   GO; GO:0008655; P:pyrimidine salvage; IEA:HAMAP.
DR   HAMAP; MF_00551; -; 1.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    207       Uridine kinase.
FT                                /FTId=PRO_1000017868.
FT   NP_BIND       9     16       ATP (Potential).
SQ   SEQUENCE   207 AA;  23998 MW;  3761FEE3551F9813 CRC64;
     MAKIIGISGG SGSGKTTVVS KISEFIPEFV LISQDNYYKS VGDYEYEFSK VNFDHPDAFD
     NNLFYEHLKN LKKNSPIDMP LYDFINHKRQ LKTVLVVPTP VIIVEGIMIF VEERVRNLID
     LKIYIDTPND IRFIRRLRRD ISKRGRTLES VIDQYLNTTR WGYYRFIEPT KEYADLIIPE
     GGHNDKALYV LSTFLKSLSK EGGLDFI
//