Q0SPE9 (URK_BORAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	BAPKO_0014

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity HAMAP MF_00551.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Uridine kinase HAMAP MF_00551		PRO_1000017868
Regions
	Nucleotide binding	9 – 16	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0SPE9 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 3761FEE3551F9813	FASTA	207	23,998
	10 20 30 40 50 60 MAKIIGISGG SGSGKTTVVS KISEFIPEFV LISQDNYYKS VGDYEYEFSK VNFDHPDAFD 70 80 90 100 110 120 NNLFYEHLKN LKKNSPIDMP LYDFINHKRQ LKTVLVVPTP VIIVEGIMIF VEERVRNLID 130 140 150 160 170 180 LKIYIDTPND IRFIRRLRRD ISKRGRTLES VIDQYLNTTR WGYYRFIEPT KEYADLIIPE 190 200 GGHNDKALYV LSTFLKSLSK EGGLDFI

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000395 Genomic DNA. Translation: ABH01279.1.
RefSeq	YP_709455.1. NC_008277.1.
3D structure databases
ProteinModelPortal	Q0SPE9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SPE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000003757; EBBORP00000003375; EBBORG00000003757.
GeneID	4227180.
GenomeReviews	Gene locus BAPKO_0014 in contig CP000395_GR.
KEGG	baf:BAPKO_0014.
NMPDR	fig|390236.5.peg.82.
PATRIC	37188329. VBIBorAfz3878_0083.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0572.
GeneTree	EBGT00050000007051.
HOGENOM	HBG527126.
OMA	NQFVEPT.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0014-MONOMER.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase. [Tree]
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
KO	K00876.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. Udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_BORAP

Accession

Primary (citable) accession number: Q0SPE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program