ID   TPIS_BORAP              Reviewed;         253 AA.
AC   Q0SPB0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=BAPKO_0055;
OS   Borrelia afzelii (strain PKo).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M.,
RA   Suehnel J., Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CP000395; ABH01318.1; -; Genomic_DNA.
DR   RefSeq; YP_709494.1; -.
DR   GeneID; 4227598; -.
DR   GenomeReviews; CP000395_GR; BAPKO_0055.
DR   KEGG; baf:BAPKO_0055; -.
DR   NMPDR; fig|390236.5.peg.120; -.
DR   HOGENOM; Q0SPB0; -.
DR   OMA; Q0SPB0; IGAQDCH.
DR   BioCyc; BAFZ390236:BAPKO_0055-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00147; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    253       Triosephosphate isomerase.
FT                                /FTId=PRO_0000307438.
FT   ACT_SITE     96     96       Electrophile (By similarity).
FT   ACT_SITE    169    169       Proton acceptor (By similarity).
FT   BINDING       9      9       Substrate (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
SQ   SEQUENCE   253 AA;  27830 MW;  EF737C12ACFCE32B CRC64;
     MRKTFLAGNW KMHYTSAEAS IVAKQIATEV KTLNDDFVIM ITPPFTALSK VSECIKGSNI
     LLGAQNMSYM ESGARTSEIS PSMLLEFGVE YVILGHSECR LYLAETDEII NKKIRAGLKH
     SFKYLILCVG ETLDERDSGK TLDVVLSQVK KGLDCVSESD IKRIILAYEP VWAIGTGKTA
     TKEEAEEVHK AIRLEIMKLY SKSASDNIII QYGGSVNASN IKELMNEPNI DGALIGGASL
     KAESFLSIIN NVR
//