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Q0SP28 (SYH_BORAP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:BAPKO_0137
OrganismBorrelia afzelii (strain PKo) [Complete proteome] [HAMAP]
Taxonomic identifier390236 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subunit structure

Homodimer By similarity. HAMAP MF_00127

Subcellular location

Cytoplasm By similarity HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Histidine--tRNA ligase HAMAP MF_00127
PRO_1000016316

Sequences

Sequence LengthMass (Da)Tools
Q0SP28 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 89BF2C1B86106692

FASTA45652,781
        10         20         30         40         50         60 
MDIKTLKGFK DYLPKDSLIR IHIVRQIFSV LNSYNFDLID TPVLEYSELL LKKSGDEAEK 

        70         80         90        100        110        120 
QIYRFKDNGG RDVSMRFDLT VPFARFIATN ASNLKFPFRR SQFGKVFRGE NSQKGRYREF 

       130        140        150        160        170        180 
MQFDFDIVGE DSFRGDAEIL SVVYYGLEEI FLNFIEGINK KFIIHYSHLG ILNSFFEKLG 

       190        200        210        220        230        240 
IKEKSLFILR NIDKIDKIGV DKVKEALLLK IEKEVVDSIL NLVNLQGTFK EKIQALKSIL 

       250        260        270        280        290        300 
GDNESVKRVE DVFQHLSLLK IQDSFNLNLK ISRGLDYYTG IVFESEVFDS NMGSVCSGGR 

       310        320        330        340        350        360 
YDNLVSSFSS SIQKISGVGG SFGVDRIKDI IDLEKFSYVK IFVTKARSKV LIVNLDSALQ 

       370        380        390        400        410        420 
DYYYELATRF RNHDYSKVKN ISCEVYFKNK NGKNIKEQIE YALSKEIRFL VFVGQEEYKE 

       430        440        450 
NKMKVRDLTK KEELLLSFEE SINVIKCSEK LLCTPF

« Hide

References

[1]"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PKo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000395 Genomic DNA. Translation: ABH01400.1.
RefSeqYP_709576.1. NC_008277.1.

3D structure databases

ProteinModelPortalQ0SP28.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SP28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000003902; EBBORP00000003520; EBBORG00000003902.
GeneID4227378.
GenomeReviewsGene locus BAPKO_0137 in contig CP000395_GR.
KEGGbaf:BAPKO_0137.
NMPDRfig|390236.5.peg.201.
PATRIC37188565. VBIBorAfz3878_0200.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
GeneTreeEBGT00050000006869.
HOGENOMHBG616575.
OMAEIFLNFI.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycBAFZ390236:BAPKO_0137-MONOMER.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_BORAP
AccessionPrimary (citable) accession number: Q0SP28
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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