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Q0SP05

- Q0SP05_BORAP

UniProt

Q0SP05 - Q0SP05_BORAP

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Protein

Alanine racemase

Gene

alr

Organism
Borrelia afzelii (strain PKo)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BafPKo_0157Imported, BAPKO_0161Imported
OrganismiBorrelia afzelii (strain PKo)Imported
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000005216: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0161.

Structurei

3D structure databases

ProteinModelPortaliQ0SP05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0SP05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSNKTIIIN LNNLEHNLNL IKNKIGEKEI VATLKGDAYG HGLINIFKFF
60 70 80 90 100
KAKKINYFGL SNIEDAKTLK KIDKSTKILM YIKVDKKEIK NLIKLELLPF
110 120 130 140 150
VADFEYLFLI EKECALQKKK IKVHLKIDVG MNRYGIKIDS ALEIATYIQN
160 170 180 190 200
SKFLELEGVC SHLPTTENFK ITQKQIEQFL FFLETLKQKN INPKFVHISN
210 220 230 240 250
SGHIINYKLN PQFNMVRPGL ILYGYCPTLK NKKTTLNFKP VLNLFSKVVF
260 270 280 290 300
IKNVKKGEKI SYSGTFQAKE DMKIGIIPIG YFDGIPQNIN NNFYFLINNK
310 320 330 340 350
KCKIRGKVCM NLTIVEIPKD LKVETGSKVE IVSEKLSINE MSKFSKRSHY
360
ELLCNIGKYE NRKYLD
Length:366
Mass (Da):42,300
Last modified:September 5, 2006 - v1
Checksum:iDCD3E95D73B80FC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei366 – 3661Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01423.1.
EF537505 Genomic DNA. Translation: ABQ43059.1.
CP002933 Genomic DNA. Translation: AEL69390.1.
RefSeqiYP_005592380.1. NC_017238.1.
YP_709599.1. NC_008277.1.

Genome annotation databases

EnsemblBacteriaiABH01423; ABH01423; BAPKO_0161.
AEL69390; AEL69390; BafPKo_0157.
GeneIDi12159112.
4227442.
KEGGibaf:BAPKO_0161.
bafz:BafPKo_0157.
PATRICi37188613. VBIBorAfz3878_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01423.1 .
EF537505 Genomic DNA. Translation: ABQ43059.1 .
CP002933 Genomic DNA. Translation: AEL69390.1 .
RefSeqi YP_005592380.1. NC_017238.1.
YP_709599.1. NC_008277.1.

3D structure databases

ProteinModelPortali Q0SP05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390236.BAPKO_0161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH01423 ; ABH01423 ; BAPKO_0161 .
AEL69390 ; AEL69390 ; BafPKo_0157 .
GeneIDi 12159112.
4227442.
KEGGi baf:BAPKO_0161.
bafz:BafPKo_0157.
PATRICi 37188613. VBIBorAfz3878_0224.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi RTEEWIA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genome analysis: Selection pressure on the Borrelia vls cassettes is essential for infectivity."
    Gloeckner G., Schulte-Spechtel U., Schilhabel M.B., Felder M., Suehnel J., Wilske B., Platzer M.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PKoImported.
  2. "Wide distribution of a high-virulence Borrelia burgdorferi clone in Europe and North America."
    Qiu W.G., Bruno J.F., McCaig W.D., Xu Y., Livey I., Schriefer M.M., Luft B.J.
    Emerg. Infect. Dis. 14:1097-1104(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PKoImported.
  3. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
    Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
    J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKoImported.

Entry informationi

Entry nameiQ0SP05_BORAP
AccessioniPrimary (citable) accession number: Q0SP05
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3