Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q0SNS0 (GLPK_BORAP)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: BAPKO_0250
OrganismBorrelia afzelii (strain PKo) [Complete proteome] [HAMAP]
Taxonomic identifier390236 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Hide | Top

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Glycerol kinase HAMAP MF_00186
PRO_1000020704

Regions

Nucleotide binding409 – 4135ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q0SNS0-1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 199AC96FDE6C624C

FASTA50155,691
        10         20         30         40         50         60 
MKYILSIDQG TTSSRAIVFD KNANIKGIAQ KEFTQIYPQP SWVEHDPTEI WGSQLGVITE 

        70         80         90        100        110        120 
ALANSRILPN EVDAIGITNQ RETTVIWEKN TGKPIYNAIV WQDRRTAKIC DQLTKEGKDK 

       130        140        150        160        170        180 
IILEKTGLVL DSYFSGTKIL WILDNVEGAR QKAENGELCF GTIDTWLLWN LTQKKVHATD 

       190        200        210        220        230        240 
YSNASRTLLL NIKTLEWDDE LLNILNIPKA ILPELKESST IYGKTDKSLF GAEIPIAGIA 

       250        260        270        280        290        300 
GDQFAATFGQ ACLKKGMAKN TYGTGCFLTV NIGKEPIINH ERLLTSIAWG RKKSVTYVLE 

       310        320        330        340        350        360 
GSVFIGGAVI QWLRDGLEFF RKSSDAESLA SSASDNGGVY FVPAFVGLGA PHWDSYARGT 

       370        380        390        400        410        420 
IIGITRGSTK AHITRAALES IAFQSFDILN TMKKSIPNFE IKELRVDGGA SQNNLLMQFQ 

       430        440        450        460        470        480 
ADLLECKVVR PKITETTALG AAYLAGLASG YWQSAEEIVS LWQVDKIFEP SMPKNQKEKL 

       490        500 
LENWNRAIER SKSWIQNSHS L

« Hide

Hide | Top

References

[1]"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000395 Genomic DNA. Translation: ABH01508.1.
RefSeqYP_709684.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4227714.
GenomeReviewsGene locus BAPKO_0250 in contig CP000395_GR.
KEGGbaf:BAPKO_0250.
NMPDRfig|390236.5.peg.302.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ0SNS0.
OMAQ0SNS0. IAQREFT.

Enzyme and pathway databases

BioCycBAFZ390236:BAPKO_0250-MON.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameGLPK_BORAP
AccessionPrimary (citable) accession number: Q0SNS0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents