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Q0SNR0

- SYL_BORAP

UniProt

Q0SNR0 - SYL_BORAP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BAPKO_0261, BafPKo_0253
OrganismiBorrelia afzelii (strain PKo)
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Leucine--tRNA ligasePRO_1000009299Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0261.

Structurei

3D structure databases

ProteinModelPortaliQ0SNR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionAdd
BLAST
Motifi617 – 6215"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0SNR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKYEFIKIE KKWQEFWDNN KTYKVIEDPN IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFARYKI LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
KKSTEENINK FKKQIKALGF AYDWDREIRT HDENYYKWTQ WIFLQLYKKG
160 170 180 190 200
LAYAKEMPVW YCPELGTVLA NEEIIQTPNG PKSERGFHNV EKKYLRQWVL
210 220 230 240 250
KITKYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGYNDKIK
260 270 280 290 300
VFTTRPDTIF GITYLVIAPE NKLVEKITKD NFKSNVLKYI KQEELKSDLK
310 320 330 340 350
RTSLEKDKSG VFTGSYAFHP ITNVKIPIWV GSYVLGTYGS GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY KLKILPVISK SGKNEILEKA FINDGISINS PDEFNNLKNS
410 420 430 440 450
EVKDKVIKWL TKNKKGKETV TYKLRDWVFS RQRYWGEPIP ILFDKLGNAI
460 470 480 490 500
PLEKNDLPLK LPETANYKPS GTGESPLSRI KNWVNVKDTD FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNSKEF ANHKKIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG HVNTKEPFKK LINQGIITAF SYQKENGVLI PNDQVIEKDN
610 620 630 640 650
KFFDKKDNKE VTQVIAKMSK SLKNVINPDG IIKEFGADSI RIYEMFMGPL
660 670 680 690 700
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KDNPPKEIMS QLHKVIKKVT
710 720 730 740 750
EDTEKLNFNT AISAMMIFIN ELSKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEYIGETPS LFKNSKWPKF DETLIIKETK EIVLQINGKI KDKILLNKET
810 820 830 840
DEEELKEIAM ENSKIKSNLF NKKIVKIIVI KNKLVNIVIK
Length:840
Mass (Da):98,167
Last modified:September 5, 2006 - v1
Checksum:iB488A7FF899B0BB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01518.1.
CP002933 Genomic DNA. Translation: AEL69479.1.
RefSeqiYP_005592469.1. NC_017238.1.
YP_709694.1. NC_008277.1.

Genome annotation databases

EnsemblBacteriaiABH01518; ABH01518; BAPKO_0261.
AEL69479; AEL69479; BafPKo_0253.
GeneIDi12159207.
4227469.
KEGGibaf:BAPKO_0261.
bafz:BafPKo_0253.
PATRICi37188810. VBIBorAfz3878_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01518.1 .
CP002933 Genomic DNA. Translation: AEL69479.1 .
RefSeqi YP_005592469.1. NC_017238.1.
YP_709694.1. NC_008277.1.

3D structure databases

ProteinModelPortali Q0SNR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390236.BAPKO_0261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH01518 ; ABH01518 ; BAPKO_0261 .
AEL69479 ; AEL69479 ; BafPKo_0253 .
GeneIDi 12159207.
4227469.
KEGGi baf:BAPKO_0261.
bafz:BafPKo_0253.
PATRICi 37188810. VBIBorAfz3878_0317.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
    Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
    BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.
  2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
    Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
    J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.

Entry informationi

Entry nameiSYL_BORAP
AccessioniPrimary (citable) accession number: Q0SNR0
Secondary accession number(s): G0IR93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3