SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0SNQ3

- UPPP_BORAP

UniProt

Q0SNQ3 - UPPP_BORAP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, BAPKO_0268, BafPKo_0260
Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:BAPKO_0268, BafPKo_0260
OrganismiBorrelia afzelii (strain PKo)
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei210 – 23021Helical; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Undecaprenyl-diphosphataseUniRule annotation
PRO_0000290690Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0268.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SNQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MINILNAIIL GIVQGITEFL PVSSSGHLLL FRHFIHLKLP IIFDIYLHFA    50
TVLVIIIYYR QRISELFSTF IRFSLRKTNK SDLTNLKLIS LILIITIVTG 100
VVGTFISKYE RMFTLPFILI NFIITGILIL MLEFKFFKID FKDNILLVGI 150
FMGLMQGLGA FPGISRSGIT IFSATVLGFN RKSAFEISFL SLIPIVFGAI 200
LLKHKEFYDI FMVLNFFEIN LGALVAFVVG IFSINLFFKM LNNKKLYYFS 250
IYLFALSITV CYFV 264
Length:264
Mass (Da):30,260
Last modified:September 5, 2006 - v1
Checksum:iA19460C4682BB66F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01525.1.
CP002933 Genomic DNA. Translation: AEL69486.1.
RefSeqiWP_004790240.1. NC_017238.1.
YP_005592476.1. NC_017238.1.
YP_709701.1. NC_008277.1.

Genome annotation databases

EnsemblBacteriaiABH01525; ABH01525; BAPKO_0268.
AEL69486; AEL69486; BafPKo_0260.
GeneIDi12159214.
4227476.
KEGGibaf:BAPKO_0268.
bafz:BafPKo_0260.
PATRICi37188824. VBIBorAfz3878_0324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH01525.1 .
CP002933 Genomic DNA. Translation: AEL69486.1 .
RefSeqi WP_004790240.1. NC_017238.1.
YP_005592476.1. NC_017238.1.
YP_709701.1. NC_008277.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390236.BAPKO_0268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH01525 ; ABH01525 ; BAPKO_0268 .
AEL69486 ; AEL69486 ; BafPKo_0260 .
GeneIDi 12159214.
4227476.
KEGGi baf:BAPKO_0268.
bafz:BafPKo_0260.
PATRICi 37188824. VBIBorAfz3878_0324.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
    Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
    BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.
  2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
    Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
    J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.

Entry informationi

Entry nameiUPPP_BORAP
AccessioniPrimary (citable) accession number: Q0SNQ3
Secondary accession number(s): G0IRA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi