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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Borrelia afzelii (strain PKo)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BAPKO_0314, BafPKo_0305
OrganismiBorrelia afzelii (strain PKo)
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000005216 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalUniRule annotationAdd BLAST21
Transmembranei62 – 82HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei130 – 150HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei328 – 348HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029401 – 351Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST351

Proteomic databases

PRIDEiQ0SNK7

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0314

Structurei

3D structure databases

SMRiQ0SNK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0SNK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYLLGLRLL KYITFRMAYA TIFAFLLSLI VGPHIILRLK KLRADQILRE
60 70 80 90 100
DGPKRHLSEK TGIPTMGGIL IFFCVFISLV FWSNILNVYF LIIVFVMFGF
110 120 130 140 150
AFLGFIDDFL KIKKKTSDGL KARFKVYGQI IFSFISVSIL YYLGGEHVSI
160 170 180 190 200
IYFPFIKSFK MDLGVFYIPF GMFILIAASN SFNLTDGLDG LAIGLSIVIT
210 220 230 240 250
GALIIIAYIT SRADFAAYLH IPNIKGSEEL VIFLGALLGG SFGFLWFNAY
260 270 280 290 300
PAKIMMGDTG SLALGAILGM TALILKSEIL FSILAGVFII ETMSVIIQVI
310 320 330 340 350
VYKKTKKRVF KMAPLHHHFE ELGWSEMQVV IRFWIIGLIF AIIALSTIKI

R
Length:351
Mass (Da):39,508
Last modified:September 5, 2006 - v1
Checksum:i9AC786C70C9B4CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000395 Genomic DNA Translation: ABH01571.1
CP002933 Genomic DNA Translation: AEL69531.1
RefSeqiWP_004790551.1, NC_017238.1

Genome annotation databases

EnsemblBacteriaiABH01571; ABH01571; BAPKO_0314
AEL69531; AEL69531; BafPKo_0305
KEGGibaf:BAPKO_0314
bafz:BafPKo_0305
PATRICifig|390236.22.peg.299

Similar proteinsi

Entry informationi

Entry nameiMRAY_BORAP
AccessioniPrimary (citable) accession number: Q0SNK7
Secondary accession number(s): G0IRM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health