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Q0SNK7 (MRAY_BORAP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BAPKO_0314
OrganismBorrelia afzelii (strain PKo) [Complete proteome] [HAMAP]
Taxonomic identifier390236 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002940

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane328 – 34821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0SNK7 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 9AC786C70C9B4CE6

FASTA35139,508
        10         20         30         40         50         60 
MFYLLGLRLL KYITFRMAYA TIFAFLLSLI VGPHIILRLK KLRADQILRE DGPKRHLSEK 

        70         80         90        100        110        120 
TGIPTMGGIL IFFCVFISLV FWSNILNVYF LIIVFVMFGF AFLGFIDDFL KIKKKTSDGL 

       130        140        150        160        170        180 
KARFKVYGQI IFSFISVSIL YYLGGEHVSI IYFPFIKSFK MDLGVFYIPF GMFILIAASN 

       190        200        210        220        230        240 
SFNLTDGLDG LAIGLSIVIT GALIIIAYIT SRADFAAYLH IPNIKGSEEL VIFLGALLGG 

       250        260        270        280        290        300 
SFGFLWFNAY PAKIMMGDTG SLALGAILGM TALILKSEIL FSILAGVFII ETMSVIIQVI 

       310        320        330        340        350 
VYKKTKKRVF KMAPLHHHFE ELGWSEMQVV IRFWIIGLIF AIIALSTIKI R

« Hide

References

[1]"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PKo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000395 Genomic DNA. Translation: ABH01571.1.
RefSeqYP_709747.1. NC_008277.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SNK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000004219; EBBORP00000003837; EBBORG00000004219.
GeneID4227231.
GenomeReviewsGene locus BAPKO_0314 in contig CP000395_GR.
KEGGbaf:BAPKO_0314.
NMPDRfig|390236.5.peg.365.
PATRIC37188916. VBIBorAfz3878_0370.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
GeneTreeEBGT00050000007216.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBAFZ390236:BAPKO_0314-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BORAP
AccessionPrimary (citable) accession number: Q0SNK7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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