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Q0SN68

- RNPA_BORAP

UniProt

Q0SN68 - RNPA_BORAP

Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. tRNA binding Source: InterPro

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P proteinUniRule annotation
    Short name:
    RNaseP proteinUniRule annotation
    Alternative name(s):
    Protein C5UniRule annotation
    Gene namesi
    Name:rnpAUniRule annotation
    Ordered Locus Names:BAPKO_0463, BafPKo_0452
    OrganismiBorrelia afzelii (strain PKo)
    Taxonomic identifieri390236 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111Ribonuclease P protein componentPRO_1000021380Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi390236.BAPKO_0463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SN68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RnpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0594.
    HOGENOMiHOG000221236.
    KOiK03536.
    OMAiRIFKECF.
    OrthoDBiEOG6CGCG9.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    HAMAPiMF_00227. RNase_P.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    [Graphical view]
    PfamiPF00825. Ribonuclease_P. 1 hit.
    [Graphical view]
    ProDomiPD003629. Ribonuclease_P. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    TIGRFAMsiTIGR00188. rnpA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0SN68-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKRNISLKS KIEIQKIFKE GNLIRFSNLN LKMFCKSNHL IYSRLLVTFS    50
    KSFRGSVKRN RVRRLFKEAF RKRLELLEGR AIDIIFVVYY DRLDLTYFSI 100
    ESLMKSLVLM V 111
    Length:111
    Mass (Da):13,343
    Last modified:September 5, 2006 - v1
    Checksum:i543DE32C7001DCC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000395 Genomic DNA. Translation: ABH01710.1.
    CP002933 Genomic DNA. Translation: AEL69664.1.
    RefSeqiYP_005592654.1. NC_017238.1.
    YP_709886.1. NC_008277.1.

    Genome annotation databases

    EnsemblBacteriaiABH01710; ABH01710; BAPKO_0463.
    AEL69664; AEL69664; BafPKo_0452.
    GeneIDi12159401.
    4227590.
    KEGGibaf:BAPKO_0463.
    bafz:BafPKo_0452.
    PATRICi37189200. VBIBorAfz3878_0504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000395 Genomic DNA. Translation: ABH01710.1 .
    CP002933 Genomic DNA. Translation: AEL69664.1 .
    RefSeqi YP_005592654.1. NC_017238.1.
    YP_709886.1. NC_008277.1.

    3D structure databases

    ProteinModelPortali Q0SN68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390236.BAPKO_0463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABH01710 ; ABH01710 ; BAPKO_0463 .
    AEL69664 ; AEL69664 ; BafPKo_0452 .
    GeneIDi 12159401.
    4227590.
    KEGGi baf:BAPKO_0463.
    bafz:BafPKo_0452.
    PATRICi 37189200. VBIBorAfz3878_0504.

    Phylogenomic databases

    eggNOGi COG0594.
    HOGENOMi HOG000221236.
    KOi K03536.
    OMAi RIFKECF.
    OrthoDBi EOG6CGCG9.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    HAMAPi MF_00227. RNase_P.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    [Graphical view ]
    Pfami PF00825. Ribonuclease_P. 1 hit.
    [Graphical view ]
    ProDomi PD003629. Ribonuclease_P. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    TIGRFAMsi TIGR00188. rnpA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
      Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
      BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PKo.
    2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
      Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
      J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PKo.

    Entry informationi

    Entry nameiRNPA_BORAP
    AccessioniPrimary (citable) accession number: Q0SN68
    Secondary accession number(s): G0IS83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3