Q0SN31 (EFTU_BORAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Tu
Short name=EF-Tu

Gene names

Name:	tuf
Ordered Locus Names:	BAPKO_0504, BafPKo_0493

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia afzelii

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Elongation factor Tu HAMAP-Rule MF_00118		PRO_1000015619
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	82 – 86	5	GTP By similarity
	Nucleotide binding	137 – 140	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0SN31 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 90CEEA2B0499A948	FASTA	394	43,354
	10 20 30 40 50 60 MAKEVFQRTK PHMNVGTIGH VDHGKTTLTA AISIYCSKLN KDAKALKYED IDNAPEEKAR 70 80 90 100 110 120 GITINARHIE YETANRHYAH VDCPGHADYI KNMITGAAQM DAAILLVAAD SGAEPQTKEH 130 140 150 160 170 180 LLLAQRMGIK KIIVFLNKLD LADPELVELV EVEVLELVEK YGFSANTPII KGSAFGAMSN 190 200 210 220 230 240 PEDPEATKCV KELLESMDNY FDLPERDIDK PFLLAVEDVF SISGRGTVAT GRIERGVIKV 250 260 270 280 290 300 GQEVEIVGIK ETRKTTVTGV EMFQKILEQG QAGDNVGLLL RGVDKKDIER GQVLSAPGTI 310 320 330 340 350 360 TPHKKFKASI YCLTKEEGGR HKPFFPGYRP QFFFRTTDVT GVVALEGKEM VMPGDNVDIV 370 380 390 VELISSIAMD KNVEFAVREG GRTVASGRIL EILE

References

[1]	"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.
[2]	"Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates." Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E. J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000395 Genomic DNA. Translation: ABH01747.1. CP002933 Genomic DNA. Translation: AEL69701.1.
RefSeq	YP_005592691.1. NC_017238.1. YP_709923.1. NC_008277.1.
3D structure databases
ProteinModelPortal	Q0SN31.
SMR	Q0SN31. Positions 2-394.
ModBase	Search...
Protein-protein interaction databases
STRING	390236.BAPKO_0504.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABH01747; ABH01747; BAPKO_0504. AEL69701; AEL69701; BafPKo_0493.
GeneID	12159441. 4227955.
KEGG	baf:BAPKO_0504. bafz:BafPKo_0493.
PATRIC	37189281. VBIBorAfz3878_0540.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0050.
HOGENOM	HOG000229290.
KO	K02358.
OMA	MAISSPA.
ProtClustDB	PRK00049.
Family and domain databases
HAMAP	MF_00118_B. EF_Tu_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR005225. Small_GTP-bd_dom. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004541. Transl_elong_EFTu/EF1A_bac/org. IPR004160. Transl_elong_EFTu/EF1A_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00485. EF-Tu. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTU_BORAP

Accession

Primary (citable) accession number: Q0SN31
Secondary accession number(s): G0ISC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program