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Q0SMR4 (SYR_BORAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:BAPKO_0625, BafPKo_0610
OrganismBorrelia afzelii (strain PKo) [Complete proteome] [HAMAP]
Taxonomic identifier390236 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000017992

Regions

Motif127 – 13711"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q0SMR4 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 75FBFA12A2D3B3B8

FASTA58567,115
        10         20         30         40         50         60 
MTKNVKKNIK DEINIIVTNL ALSKNIKLDE ININIQKPPK SDLGDISILI FELSKTLKLP 

        70         80         90        100        110        120 
IETISEEIIK ALKAKYEIKA MGPYLNIKIP RKEYIHNTIQ MVNAQKDTYG TSKYLDNKKI 

       130        140        150        160        170        180 
ILEFSSPNTN KPLHVGHLRN DVIGESLSRI LKAVGAKIIK LNLINDRGVH ICKSMLAYKK 

       190        200        210        220        230        240 
FGNEITPEKA FKKGDHFIGD FYVQYNKYAQ ENENAEEEIQ DLLLKWEQKD ASTIELWKKL 

       250        260        270        280        290        300 
NNWAIEGIKE TYKITNTSFD KIYLESEIFE IGKNVVLEGL EKGFCYKRED GAICIDLPLD 

       310        320        330        340        350        360 
SDEKTDTKVK QKVLIRSNGT SIYLTQDLGN IAVRIKEFNF EEMIYVVGSE QIQHFKNLFF 

       370        380        390        400        410        420 
VSEKLGISKN KKLFHLSHGM VNLVDGKMKS REGNVIDGDN LILDLMESIL PEITQKIENK 

       430        440        450        460        470        480 
ENAKKNALDI ALGAIHYYLL KSAIHKDIVF NKKESLSFTG NSGPYIQYVG ARINSILEKY 

       490        500        510        520        530        540 
NTLSIPIIKK INFELLEHEK EWDIIKIISE LEENIIKAAK DLNPSILTSY SYSLAKHFSA 

       550        560        570        580 
YYQEVRVIDI NNIDLTAARI EFLKAILQTI KNCMYLLNIP YMLKM 

« Hide

References

[1]"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PKo.
[2]"Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PKo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000395 Genomic DNA. Translation: ABH01864.1.
CP002933 Genomic DNA. Translation: AEL69814.1.
RefSeqYP_005592804.1. NC_017238.1.
YP_710040.1. NC_008277.1.

3D structure databases

ProteinModelPortalQ0SMR4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390236.BAPKO_0625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABH01864; ABH01864; BAPKO_0625.
AEL69814; AEL69814; BafPKo_0610.
GeneID12159558.
4227928.
KEGGbaf:BAPKO_0625.
bafz:BafPKo_0610.
PATRIC37189517. VBIBorAfz3878_0654.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMADGTAVYM.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_BORAP
AccessionPrimary (citable) accession number: Q0SMR4
Secondary accession number(s): G0IQE4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries