Reviewed, UniProtKB/Swiss-Prot Q0SMR4 (SYR_BORAP)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BAPKO_0625

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_1000017992
Regions
	Motif	127 – 137	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q0SMR4-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 75FBFA12A2D3B3B8	FASTA	585	67,115
	10 20 30 40 50 60 MTKNVKKNIK DEINIIVTNL ALSKNIKLDE ININIQKPPK SDLGDISILI FELSKTLKLP 70 80 90 100 110 120 IETISEEIIK ALKAKYEIKA MGPYLNIKIP RKEYIHNTIQ MVNAQKDTYG TSKYLDNKKI 130 140 150 160 170 180 ILEFSSPNTN KPLHVGHLRN DVIGESLSRI LKAVGAKIIK LNLINDRGVH ICKSMLAYKK 190 200 210 220 230 240 FGNEITPEKA FKKGDHFIGD FYVQYNKYAQ ENENAEEEIQ DLLLKWEQKD ASTIELWKKL 250 260 270 280 290 300 NNWAIEGIKE TYKITNTSFD KIYLESEIFE IGKNVVLEGL EKGFCYKRED GAICIDLPLD 310 320 330 340 350 360 SDEKTDTKVK QKVLIRSNGT SIYLTQDLGN IAVRIKEFNF EEMIYVVGSE QIQHFKNLFF 370 380 390 400 410 420 VSEKLGISKN KKLFHLSHGM VNLVDGKMKS REGNVIDGDN LILDLMESIL PEITQKIENK 430 440 450 460 470 480 ENAKKNALDI ALGAIHYYLL KSAIHKDIVF NKKESLSFTG NSGPYIQYVG ARINSILEKY 490 500 510 520 530 540 NTLSIPIIKK INFELLEHEK EWDIIKIISE LEENIIKAAK DLNPSILTSY SYSLAKHFSA 550 560 570 580 YYQEVRVIDI NNIDLTAARI EFLKAILQTI KNCMYLLNIP YMLKM

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000395 Genomic DNA. Translation: ABH01864.1.
RefSeq	YP_710040.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4227928.
GenomeReviews	Gene locus BAPKO_0625 in contig CP000395_GR.
KEGG	baf:BAPKO_0625.
NMPDR	fig|390236.5.peg.650.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SMR4.
OMA	Q0SMR4. SHITELL.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0625-MON.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BORAP

Accession

Primary (citable) accession number: Q0SMR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)