Q0SMR4 (SYR_BORAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BAPKO_0625, BafPKo_0610

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia afzelii

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_1000017992
Regions
	Motif	127 – 137	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q0SMR4 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 75FBFA12A2D3B3B8	FASTA	585	67,115
	10 20 30 40 50 60 MTKNVKKNIK DEINIIVTNL ALSKNIKLDE ININIQKPPK SDLGDISILI FELSKTLKLP 70 80 90 100 110 120 IETISEEIIK ALKAKYEIKA MGPYLNIKIP RKEYIHNTIQ MVNAQKDTYG TSKYLDNKKI 130 140 150 160 170 180 ILEFSSPNTN KPLHVGHLRN DVIGESLSRI LKAVGAKIIK LNLINDRGVH ICKSMLAYKK 190 200 210 220 230 240 FGNEITPEKA FKKGDHFIGD FYVQYNKYAQ ENENAEEEIQ DLLLKWEQKD ASTIELWKKL 250 260 270 280 290 300 NNWAIEGIKE TYKITNTSFD KIYLESEIFE IGKNVVLEGL EKGFCYKRED GAICIDLPLD 310 320 330 340 350 360 SDEKTDTKVK QKVLIRSNGT SIYLTQDLGN IAVRIKEFNF EEMIYVVGSE QIQHFKNLFF 370 380 390 400 410 420 VSEKLGISKN KKLFHLSHGM VNLVDGKMKS REGNVIDGDN LILDLMESIL PEITQKIENK 430 440 450 460 470 480 ENAKKNALDI ALGAIHYYLL KSAIHKDIVF NKKESLSFTG NSGPYIQYVG ARINSILEKY 490 500 510 520 530 540 NTLSIPIIKK INFELLEHEK EWDIIKIISE LEENIIKAAK DLNPSILTSY SYSLAKHFSA 550 560 570 580 YYQEVRVIDI NNIDLTAARI EFLKAILQTI KNCMYLLNIP YMLKM

References

[1]	"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.
[2]	"Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates." Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E. J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000395 Genomic DNA. Translation: ABH01864.1. CP002933 Genomic DNA. Translation: AEL69814.1.
RefSeq	YP_005592804.1. NC_017238.1. YP_710040.1. NC_008277.1.
3D structure databases
ProteinModelPortal	Q0SMR4.
ModBase	Search...
Protein-protein interaction databases
STRING	390236.BAPKO_0625.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABH01864; ABH01864; BAPKO_0625. AEL69814; AEL69814; BafPKo_0610.
GeneID	12159558. 4227928.
KEGG	baf:BAPKO_0625. bafz:BafPKo_0610.
PATRIC	37189517. VBIBorAfz3878_0654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247211.
KO	K01887.
OMA	ESELGWE.
ProtClustDB	PRK01611.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BORAP

Accession

Primary (citable) accession number: Q0SMR4
Secondary accession number(s): G0IQE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program