ID   NANE_BORAP              Reviewed;         232 AA.
AC   Q0SMK9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE; OrderedLocusNames=BAPKO_0688;
OS   Borrelia afzelii (strain PKo).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M.,
RA   Suehnel J., Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to
CC       N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential).
CC   -!- CATALYTIC ACTIVITY: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 3/5.
CC   -!- SIMILARITY: Belongs to the nanE family.
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DR   EMBL; CP000395; ABH01919.1; -; Genomic_DNA.
DR   RefSeq; YP_710095.1; -.
DR   GeneID; 4227855; -.
DR   GenomeReviews; CP000395_GR; BAPKO_0688.
DR   KEGG; baf:BAPKO_0688; -.
DR   NMPDR; fig|390236.5.peg.702; -.
DR   HOGENOM; Q0SMK9; -.
DR   OMA; Q0SMK9; YNTPELA.
DR   BioCyc; BAFZ390236:BAPKO_0688-MON; -.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase a...; IEA:EC.
DR   GO; GO:0004789; F:thiamin-phosphate diphosphorylase activity; IEA:InterPro.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   GO; GO:0009228; P:thiamin biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01235; -; 1.
DR   InterPro; IPR007260; NanE.
DR   Pfam; PF04131; NanE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase.
FT   CHAIN         1    232       Putative N-acetylmannosamine-6-phosphate
FT                                2-epimerase.
FT                                /FTId=PRO_0000301466.
SQ   SEQUENCE   232 AA;  25684 MW;  BD4E62280D37BF05 CRC64;
     MIIIEKIKRG LIVSCQALEN EPLHSSFIMS KMALAAKMGG AIGIRANGVN DISQIKLEVD
     LPIIGIIKRN YNNCDVFITP TMKEIDELCN EGVDIIALDA TFRNRPDSVS LDDFFKSIKK
     KYPKQCLMAD ISSLDEAINA DKLGFDFIGT TLYGYTKSTN GLDIADNDFN FLKTLINSNL
     KSTLIVEGKI DTPLKAQKCF EMGVDLVVVG GAITRPVEIT KKFVEKINQV KR
//