Q0SMK9 (NANE_BORAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosamine-6-phosphate 2-epimerase
EC=5.1.3.9

Alternative name(s):
ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	BAPKO_0688

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential. HAMAP MF_01235
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301466

Sequences

	Sequence		Length	Mass (Da)
	Q0SMK9 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: BD4E62280D37BF05	FASTA	232	25,684
	10 20 30 40 50 60 MIIIEKIKRG LIVSCQALEN EPLHSSFIMS KMALAAKMGG AIGIRANGVN DISQIKLEVD 70 80 90 100 110 120 LPIIGIIKRN YNNCDVFITP TMKEIDELCN EGVDIIALDA TFRNRPDSVS LDDFFKSIKK 130 140 150 160 170 180 KYPKQCLMAD ISSLDEAINA DKLGFDFIGT TLYGYTKSTN GLDIADNDFN FLKTLINSNL 190 200 210 220 230 KSTLIVEGKI DTPLKAQKCF EMGVDLVVVG GAITRPVEIT KKFVEKINQV KR

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000395 Genomic DNA. Translation: ABH01919.1.
RefSeq	YP_710095.1. NC_008277.1.
3D structure databases
ProteinModelPortal	Q0SMK9.
SMR	Q0SMK9. Positions 7-227.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SMK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000003906; EBBORP00000003524; EBBORG00000003906.
GeneID	4227855.
GenomeReviews	Gene locus BAPKO_0688 in contig CP000395_GR.
KEGG	baf:BAPKO_0688.
NMPDR	fig|390236.5.peg.702.
PATRIC	37189633. VBIBorAfz3878_0704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3010.
GeneTree	EBGT00050000007531.
HOGENOM	HBG296941.
OMA	CQALEDE.
ProtClustDB	PRK01130.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0688-MONOMER.
Family and domain databases
HAMAP	MF_01235. ManNAc6P_epimer. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR007260. NanE. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF04131. NanE. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NANE_BORAP

Accession

Primary (citable) accession number: Q0SMK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program