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Q0SMJ5

- GPMA_BORAP

UniProt

Q0SMJ5 - GPMA_BORAP

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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
Active sitei182 – 1821UniRule annotation
Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:BAPKO_0702, BafPKo_0682
OrganismiBorrelia afzelii (strain PKo)
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482482,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_1000064033Add
BLAST

Proteomic databases

PRIDEiQ0SMJ5.

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0702.

Structurei

3D structure databases

ProteinModelPortaliQ0SMJ5.
SMRiQ0SMJ5. Positions 2-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiKDDERFP.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0SMJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKLVLVRHG ESEWNKENLF TGWTDVKLSD KGVDEAIEAG LLLKQEGYFF
60 70 80 90 100
DIAFSSLLSR ANDTLNIILK ELGQSYISVK KTWRLNERHY GALQGLNKSE
110 120 130 140 150
TAAKYGEDKV LIWRRSYDVP PMSLDESDDR HPIKDPRYKY IPKRELPSTE
160 170 180 190 200
CLKDTIARVI PYWIDEIAKE ILEGKKVIVA AHGNSLRALV KYLDNLSEED
210 220 230 240
VLKLNIPTGI PLVYELDKDL NPIKHYYLGD ENKIKKAMES VASQGKLR
Length:248
Mass (Da):28,499
Last modified:September 5, 2006 - v1
Checksum:i342F369B47AB0E0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000395 Genomic DNA. Translation: ABH01933.1.
CP002933 Genomic DNA. Translation: AEL69878.1.
RefSeqiWP_004790089.1. NC_017238.1.
YP_005592868.1. NC_017238.1.
YP_710109.1. NC_008277.1.

Genome annotation databases

EnsemblBacteriaiABH01933; ABH01933; BAPKO_0702.
AEL69878; AEL69878; BafPKo_0682.
GeneIDi12158770.
4227649.
KEGGibaf:BAPKO_0702.
bafz:BafPKo_0682.
PATRICi37189661. VBIBorAfz3878_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000395 Genomic DNA. Translation: ABH01933.1 .
CP002933 Genomic DNA. Translation: AEL69878.1 .
RefSeqi WP_004790089.1. NC_017238.1.
YP_005592868.1. NC_017238.1.
YP_710109.1. NC_008277.1.

3D structure databases

ProteinModelPortali Q0SMJ5.
SMRi Q0SMJ5. Positions 2-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390236.BAPKO_0702.

Proteomic databases

PRIDEi Q0SMJ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH01933 ; ABH01933 ; BAPKO_0702 .
AEL69878 ; AEL69878 ; BafPKo_0682 .
GeneIDi 12158770.
4227649.
KEGGi baf:BAPKO_0702.
bafz:BafPKo_0682.
PATRICi 37189661. VBIBorAfz3878_0718.

Phylogenomic databases

eggNOGi COG0588.
HOGENOMi HOG000221682.
KOi K01834.
OMAi KDDERFP.
OrthoDBi EOG6C8N1H.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
HAMAPi MF_01039. PGAM_GpmA.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view ]
PANTHERi PTHR11931. PTHR11931. 1 hit.
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
TIGRFAMsi TIGR01258. pgm_1. 1 hit.
PROSITEi PS00175. PG_MUTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
    Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
    BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.
  2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
    Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
    J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.

Entry informationi

Entry nameiGPMA_BORAP
AccessioniPrimary (citable) accession number: Q0SMJ5
Secondary accession number(s): G0IQK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3