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Q0SMJ5

- GPMA_BORAP

UniProt

Q0SMJ5 - GPMA_BORAP

Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
    Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
    Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
    Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
    Active sitei182 – 1821UniRule annotation
    Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
    Short name:
    BPG-dependent PGAMUniRule annotation
    Short name:
    PGAMUniRule annotation
    Short name:
    PhosphoglyceromutaseUniRule annotation
    Short name:
    dPGMUniRule annotation
    Gene namesi
    Name:gpmAUniRule annotation
    Ordered Locus Names:BAPKO_0702, BafPKo_0682
    OrganismiBorrelia afzelii (strain PKo)
    Taxonomic identifieri390236 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2482482,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_1000064033Add
    BLAST

    Proteomic databases

    PRIDEiQ0SMJ5.

    Interactioni

    Protein-protein interaction databases

    STRINGi390236.BAPKO_0702.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SMJ5.
    SMRiQ0SMJ5. Positions 2-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
    Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
    Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0588.
    HOGENOMiHOG000221682.
    KOiK01834.
    OMAiKDDERFP.
    OrthoDBiEOG6C8N1H.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    HAMAPiMF_01039. PGAM_GpmA.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view]
    PANTHERiPTHR11931. PTHR11931. 1 hit.
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    TIGRFAMsiTIGR01258. pgm_1. 1 hit.
    PROSITEiPS00175. PG_MUTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0SMJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKLVLVRHG ESEWNKENLF TGWTDVKLSD KGVDEAIEAG LLLKQEGYFF    50
    DIAFSSLLSR ANDTLNIILK ELGQSYISVK KTWRLNERHY GALQGLNKSE 100
    TAAKYGEDKV LIWRRSYDVP PMSLDESDDR HPIKDPRYKY IPKRELPSTE 150
    CLKDTIARVI PYWIDEIAKE ILEGKKVIVA AHGNSLRALV KYLDNLSEED 200
    VLKLNIPTGI PLVYELDKDL NPIKHYYLGD ENKIKKAMES VASQGKLR 248
    Length:248
    Mass (Da):28,499
    Last modified:September 5, 2006 - v1
    Checksum:i342F369B47AB0E0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000395 Genomic DNA. Translation: ABH01933.1.
    CP002933 Genomic DNA. Translation: AEL69878.1.
    RefSeqiYP_005592868.1. NC_017238.1.
    YP_710109.1. NC_008277.1.

    Genome annotation databases

    EnsemblBacteriaiABH01933; ABH01933; BAPKO_0702.
    AEL69878; AEL69878; BafPKo_0682.
    GeneIDi12158770.
    4227649.
    KEGGibaf:BAPKO_0702.
    bafz:BafPKo_0682.
    PATRICi37189661. VBIBorAfz3878_0718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000395 Genomic DNA. Translation: ABH01933.1 .
    CP002933 Genomic DNA. Translation: AEL69878.1 .
    RefSeqi YP_005592868.1. NC_017238.1.
    YP_710109.1. NC_008277.1.

    3D structure databases

    ProteinModelPortali Q0SMJ5.
    SMRi Q0SMJ5. Positions 2-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390236.BAPKO_0702.

    Proteomic databases

    PRIDEi Q0SMJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABH01933 ; ABH01933 ; BAPKO_0702 .
    AEL69878 ; AEL69878 ; BafPKo_0682 .
    GeneIDi 12158770.
    4227649.
    KEGGi baf:BAPKO_0702.
    bafz:BafPKo_0682.
    PATRICi 37189661. VBIBorAfz3878_0718.

    Phylogenomic databases

    eggNOGi COG0588.
    HOGENOMi HOG000221682.
    KOi K01834.
    OMAi KDDERFP.
    OrthoDBi EOG6C8N1H.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    HAMAPi MF_01039. PGAM_GpmA.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view ]
    PANTHERi PTHR11931. PTHR11931. 1 hit.
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    TIGRFAMsi TIGR01258. pgm_1. 1 hit.
    PROSITEi PS00175. PG_MUTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
      Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
      BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PKo.
    2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
      Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
      J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PKo.

    Entry informationi

    Entry nameiGPMA_BORAP
    AccessioniPrimary (citable) accession number: Q0SMJ5
    Secondary accession number(s): G0IQK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3