Reviewed, UniProtKB/Swiss-Prot Q0SMG9 (IDI2_BORAP)

Names and origin

Protein names

Recommended name:
    Isopentenyl-diphosphate delta-isomerase
      Short name=IPP isomerase
    EC=5.3.3.2
Alternative name(s):
    Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	BAPKO_0728

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity.
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_1000048435

Sequences

	Sequence		Length	Mass (Da)
	Q0SMG9-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 093F76B2A945AE15	FASTA	354	39,148
	10 20 30 40 50 60 MGIEPNILEN KKRHIDICLN KNDVKSGCNF LRFVKLKHNA LSDFNFSEID IKEEIFGYNI 70 80 90 100 110 120 SMPVFISSMT GGGKEGNDFN KSLVKIANYL KIPIGLGSFK LLFKYPEYIR DFALKRYAHS 130 140 150 160 170 180 IPLFANIGAV QIVEFGISRI VEMIKRLEVD AIIVHLNAGQ ELMNVNGDRN FKGIKESIAK 190 200 210 220 230 240 LSNFISVPLI VKETGFGISP SDVKKLFQLG VSYIDLAGSG GTNWVLVEGM KGNNLNIASC 250 260 270 280 290 300 FSDWGIPSIF TLLSINDSLK ANIFASGGYE TGMDIAKGIA LGAKLIGVAA VVLRAFYDSG 310 320 330 340 350 EDAVFSLFSD YEHVLKMSMF LSGSKSLSDF RNNKYFLSSY LLAEFGVFKQ FYGT

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000395 Genomic DNA. Translation: ABH01959.1.
RefSeq	YP_710135.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4227970.
GenomeReviews	Gene locus BAPKO_0728 in contig CP000395_GR.
KEGG	baf:BAPKO_0728.
NMPDR	fig|390236.5.peg.742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SMG9.
OMA	Q0SMG9. AMGVGSQ.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0728-MON.
Family and domain databases
HAMAP	MF_00354. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_BORAP

Accession

Primary (citable) accession number: Q0SMG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 19, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)