Q0SMF0 (RNC_BORAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	BAPKO_0748

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. HAMAP MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity HAMAP MF_00104.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Ribonuclease 3 HAMAP MF_00104		PRO_1000075728
Regions
	Domain	18 – 146	129	RNase III
	Domain	173 – 242	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q0SMF0 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 93B257858F92DC85	FASTA	245	27,837
	10 20 30 40 50 60 MKKNSSDFCF SNERKAQLSE FLENLSIDFN NFDLLNTALS HSSYSNELDQ KSDNNERLEF 70 80 90 100 110 120 LGDSVLNLII TDHLYKTYPN KSEGELSKAR SYIVSEDSLS SIAREIDLGS YILLGRGEES 130 140 150 160 170 180 NDGRNKKGIL ADAIEAFVGA IYLDSGFLIA TEFVVGLFDM YIRLMFNRGD FKDYKSLLQE 190 200 210 220 230 240 YVQKKYKISP NYKLDKEIGP DHDKVFCVEL YVGEKFISNG KGKSKKEAEM RAAEVALKAM EDINL

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PKo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000395 Genomic DNA. Translation: ABH01978.1.
RefSeq	YP_710154.1. NC_008277.1.
3D structure databases
ProteinModelPortal	Q0SMF0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SMF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000004106; EBBORP00000003724; EBBORG00000004106.
GeneID	4227084.
GenomeReviews	Gene locus BAPKO_0748 in contig CP000395_GR.
KEGG	baf:BAPKO_0748.
NMPDR	fig|390236.5.peg.760.
PATRIC	37189753. VBIBorAfz3878_0763.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0571.
GeneTree	EBGT00050000007579.
HOGENOM	HBG744556.
OMA	ALTHKSF.
ProtClustDB	PRK00102.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0748-MONOMER.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
KO	K03685.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_BORAP

Accession

Primary (citable) accession number: Q0SMF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program