ID   G6PI_BORAP              Reviewed;         530 AA.
AC   Q0SMC6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Glucose-6-phosphate isomerase;
DE            Short=GPI;
DE            EC=5.3.1.9;
DE   AltName: Full=Phosphoglucose isomerase;
DE            Short=PGI;
DE   AltName: Full=Phosphohexose isomerase;
DE            Short=PHI;
GN   Name=pgi; OrderedLocusNames=BAPKO_0774;
OS   Borrelia afzelii (strain PKo).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M.,
RA   Suehnel J., Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the GPI family.
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DR   EMBL; CP000395; ABH02002.1; -; Genomic_DNA.
DR   RefSeq; YP_710178.1; -.
DR   GeneID; 4227073; -.
DR   GenomeReviews; CP000395_GR; BAPKO_0774.
DR   KEGG; baf:BAPKO_0774; -.
DR   NMPDR; fig|390236.5.peg.784; -.
DR   HOGENOM; Q0SMC6; -.
DR   OMA; Q0SMC6; GPKIVSQ.
DR   BioCyc; BAFZ390236:BAPKO_0774-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00473; -; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   PANTHER; PTHR11469; G6P_Isomerase; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT   CHAIN         1    530       Glucose-6-phosphate isomerase.
FT                                /FTId=PRO_1000013943.
FT   ACT_SITE    356    356       Proton donor (By similarity).
FT   ACT_SITE    387    387       By similarity.
FT   ACT_SITE    502    502       By similarity.
SQ   SEQUENCE   530 AA;  60223 MW;  9CCFE79D9FDDED10 CRC64;
     MINYKNLNEL ENFKILERID PEVLKTVLTG KRIKEYDITI EGDSVHYNYA SKQINENHLK
     IFQNLSDEAN LIEKYKEILN GERVNISENR KVLHHLTRGQ IGKDVIEDNK ENMREFFQSE
     LEKIYNFAKQ IHSGNIKSAN GKKFKNVVQI GIGGSSLGPK ALYSSIKNYA KKHNLALMNG
     YFISNIDPDE SAEVLNSINI DETLFIIVSK SGNTLETKAN MQFLINKLKS NGIKEYKKQM
     VIITLKNSML ALEEKGYLEY FFMHDSIGGR FSPTSAVGLV LLALCFTEKI VKEILKGANK
     ADKKSLNKNV KDNAPLLAAL ISIYERNVLN YSSNCIIAYS KAMENFYLHL QQLEMESNGK
     SVNRFNETIN YKTVRIIWGG IGTDVQHSFF QMLHQGTDIV PMDFIGFNET QLKEDVISDN
     SSSNDKLKAN LIAQIIAFSK GKENSNKNKN FKGERPSALI YSKELTPYAI GSILSHYENK
     VMFEGFLLNI NSFDQEGVQL GKTLANQILK NDTFEDEAIE SYSKKILKQD
//