Reviewed, UniProtKB/Swiss-Prot Q0SMC6 (G6PI_BORAP)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BAPKO_0774

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013943
Sites
	Active site	356	1	Proton donor By similarity
	Active site	387	1	By similarity
	Active site	502	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0SMC6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 9CCFE79D9FDDED10	FASTA	530	60,223
	10 20 30 40 50 60 MINYKNLNEL ENFKILERID PEVLKTVLTG KRIKEYDITI EGDSVHYNYA SKQINENHLK 70 80 90 100 110 120 IFQNLSDEAN LIEKYKEILN GERVNISENR KVLHHLTRGQ IGKDVIEDNK ENMREFFQSE 130 140 150 160 170 180 LEKIYNFAKQ IHSGNIKSAN GKKFKNVVQI GIGGSSLGPK ALYSSIKNYA KKHNLALMNG 190 200 210 220 230 240 YFISNIDPDE SAEVLNSINI DETLFIIVSK SGNTLETKAN MQFLINKLKS NGIKEYKKQM 250 260 270 280 290 300 VIITLKNSML ALEEKGYLEY FFMHDSIGGR FSPTSAVGLV LLALCFTEKI VKEILKGANK 310 320 330 340 350 360 ADKKSLNKNV KDNAPLLAAL ISIYERNVLN YSSNCIIAYS KAMENFYLHL QQLEMESNGK 370 380 390 400 410 420 SVNRFNETIN YKTVRIIWGG IGTDVQHSFF QMLHQGTDIV PMDFIGFNET QLKEDVISDN 430 440 450 460 470 480 SSSNDKLKAN LIAQIIAFSK GKENSNKNKN FKGERPSALI YSKELTPYAI GSILSHYENK 490 500 510 520 530 VMFEGFLLNI NSFDQEGVQL GKTLANQILK NDTFEDEAIE SYSKKILKQD

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000395 Genomic DNA. Translation: ABH02002.1.
RefSeq	YP_710178.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4227073.
GenomeReviews	Gene locus BAPKO_0774 in contig CP000395_GR.
KEGG	baf:BAPKO_0774.
NMPDR	fig|390236.5.peg.784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SMC6.
OMA	Q0SMC6. GPKIVSQ.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0774-MON.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BORAP

Accession

Primary (citable) accession number: Q0SMC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)