Reviewed, UniProtKB/Swiss-Prot Q0SM77 (APT_BORAP)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	BAPKO_0826

Organism

Borrelia afzelii (strain PKo) [Complete proteome] [HAMAP]

Taxonomic identifier

390236 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_1000000260

Sequences

	Sequence		Length	Mass (Da)
	Q0SM77-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: E18DBF0FDC5C894F	FASTA	176	20,175
	10 20 30 40 50 60 MKNKTEYYDQ FIAKVPNFPK KGILFYDITS VLLKPEVYTS LINEVYSFYN LKKIDCIAVV 70 80 90 100 110 120 ESRGYLIGAP LSLKMQLPLV LIRKEGKLPR EVFGEEYELE YGFGRIEVHK DDVRMYSNIL 130 140 150 160 170 LIDDILATGG TLKSSAILLE RAGGRVKNIF CFIELCGING RRILEGYKVN SLVRYD

References

[1]

"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity." Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M. BMC Genomics 7:211-211(2006) [PubMed: 16914037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000395 Genomic DNA. Translation: ABH02051.1.
RefSeq	YP_710227.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SM77.
Genome annotation databases
GeneID	4227892.
GenomeReviews	Gene locus BAPKO_0826 in contig CP000395_GR.
KEGG	baf:BAPKO_0826.
NMPDR	fig|390236.5.peg.831.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SM77.
OMA	KPGKLPA.
Enzyme and pathway databases
BioCyc	BAFZ390236:BAPKO_0826-MON.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BORAP

Accession

Primary (citable) accession number: Q0SM77

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)