ID   PTH_BORAP               Reviewed;         188 AA.
AC   Q0SM65;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Peptidyl-tRNA hydrolase;
DE            Short=PTH;
DE            EC=3.1.1.29;
GN   Name=pth; OrderedLocusNames=BAPKO_0839;
OS   Borrelia afzelii (strain PKo).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M.,
RA   Suehnel J., Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
CC   -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-
CC       tRNAs which drop off the ribosome during protein synthesis (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-
CC       substituted amino acid + tRNA.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PTH family.
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DR   EMBL; CP000395; ABH02063.1; -; Genomic_DNA.
DR   RefSeq; YP_710239.1; -.
DR   GeneID; 4227324; -.
DR   GenomeReviews; CP000395_GR; BAPKO_0839.
DR   KEGG; baf:BAPKO_0839; -.
DR   NMPDR; fig|390236.5.peg.841; -.
DR   HOGENOM; Q0SM65; -.
DR   OMA; Q0SM65; IKFKTGG.
DR   BioCyc; BAFZ390236:BAPKO_0839-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:HAMAP.
DR   GO; GO:0006412; P:translation; IEA:HAMAP.
DR   HAMAP; MF_00083; -; 1.
DR   InterPro; IPR001328; Pept_tRNA_hydro.
DR   InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR   Gene3D; G3DSA:3.40.50.1470; Pept_tRNA_hydro; 1.
DR   PANTHER; PTHR17224; Pept_tRNA_hydro; 1.
DR   Pfam; PF01195; Pept_tRNA_hydro; 1.
DR   ProDom; PD005324; PeptRNAhydrolase; 1.
DR   TIGRFAMs; TIGR00447; pth; 1.
DR   PROSITE; PS01195; PEPT_TRNA_HYDROL_1; 1.
DR   PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase.
FT   CHAIN         1    188       Peptidyl-tRNA hydrolase.
FT                                /FTId=PRO_0000264009.
SQ   SEQUENCE   188 AA;  21334 MW;  00E472DCD36367BF CRC64;
     MGLLILGLGN PGLEFSLTRH NVGFSLLDKI VSKNGLFLKR KKKYEYSELR VISRRVILVK
     PLTYMNLSGS LFPSIFSDFY MCIKNLLVVL DNVDLPLGKC RLKERGGMST HNGLKSISSV
     LGSSNYSRLY IGVGSNVMRD IKSFVLSRFC KDEIDRLEKL YDFLSDELID ISESNFKDKV
     QKINSSNF
//