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Q0SM46

- PNP_BORAP

UniProt

Q0SM46 - PNP_BORAP

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, BAPKO_0858, BafPKo_0833
Organism
Borrelia afzelii (strain PKo)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861Magnesium By similarity
Metal bindingi492 – 4921Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BAPKO_0858, BafPKo_0833
OrganismiBorrelia afzelii (strain PKo)
Taxonomic identifieri390236 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001825: Chromosome, UP000005216: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329539Add
BLAST

Proteomic databases

PRIDEiQ0SM46.

Interactioni

Protein-protein interaction databases

STRINGi390236.BAPKO_0858.

Structurei

3D structure databases

ProteinModelPortaliQ0SM46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KH
Add
BLAST
Domaini622 – 71796S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0SM46-1 [UniParc]FASTAAdd to Basket

« Hide

MRKILKLKIG RDELVFETGF MAKQANGSVL ATYGGSSVLA TVCCSNNVRE    50
DLDFVPLSVE YNEKYYAAGK IPGGFIKREG KPKDKEILVS RLIDRPMRPL 100
FDKRFGREIQ VIPTTLATDQ LNPPDIVGMN AAFTAVFLSD IPFNGPIAAV 150
RMVYLNGKFI VNPSFEEIHD SDLDIVVAGS LNGITMVEGG ANEVSEDILL 200
SAIDSAHEYI KQICNAQKEF LDIVGEKEKL PLAFEEKIFE FKEELRDFIY 250
ADLKEACFVK GKLNRDKAIT LLRNKSYEHF SSLEKLDDSN ESLFYKAFDD 300
FEKEIVRNSI LNDKIRTDGR TPNEIRDILA EVDILSRTHG SSLFTRGETQ 350
ALAVTTLGTS IDEQIMDDID GDKRLNFMLH YNFPPFSVGE TGRLMTGRRE 400
IGHGHLAQRA LESMIPGKND FPYTIRVVSE ILESNGSSSM ATVCAGSMSL 450
MSAGVPVKRQ VAGIAMGLIS EGDKYVVLSD ILGEEDHLGD MDFKVAGTEN 500
GITGFQMDIK IENVTKQLMR DALEQARVGR IHILSIMNSV ISNSRVGISK 550
YAPKIIQLQI DIDKISLVIG STGKTVKAIT DEFEVKVQIE QNGKIILFGD 600
DDFKMQKAKE KIESIVREPK VGEIYEGTVK KINSFGAFIE LTPTKEGFLS 650
TRLKSRDSKY GSGRFGHGNR YSRFGSGGDN IRGNAGLVRP PKLEEGQRIK 700
VRIVDIDKFG KIDLEIVRDK DY 722
Length:722
Mass (Da):80,376
Last modified:September 5, 2006 - v1
Checksum:i9BCAB9C88DC5E0FB
GO

Sequence cautioni

The sequence AEL70022.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH02082.1.
CP002933 Genomic DNA. Translation: AEL70022.1. Different initiation.
RefSeqiYP_005593012.1. NC_017238.1.
YP_710258.1. NC_008277.1.

Genome annotation databases

EnsemblBacteriaiABH02082; ABH02082; BAPKO_0858.
AEL70022; AEL70022; BafPKo_0833.
GeneIDi12158927.
4227019.
KEGGibaf:BAPKO_0858.
bafz:BafPKo_0833.
PATRICi37189963. VBIBorAfz3878_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000395 Genomic DNA. Translation: ABH02082.1 .
CP002933 Genomic DNA. Translation: AEL70022.1 . Different initiation.
RefSeqi YP_005593012.1. NC_017238.1.
YP_710258.1. NC_008277.1.

3D structure databases

ProteinModelPortali Q0SM46.
ModBasei Search...

Protein-protein interaction databases

STRINGi 390236.BAPKO_0858.

Proteomic databases

PRIDEi Q0SM46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABH02082 ; ABH02082 ; BAPKO_0858 .
AEL70022 ; AEL70022 ; BafPKo_0833 .
GeneIDi 12158927.
4227019.
KEGGi baf:BAPKO_0858.
bafz:BafPKo_0833.
PATRICi 37189963. VBIBorAfz3878_0862.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 2 hits.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity."
    Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J., Wilske B., Platzer M.
    BMC Genomics 7:211-211(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.
  2. "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates."
    Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J., Fraser-Liggett C.M., Schutzer S.E.
    J. Bacteriol. 193:6995-6996(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PKo.

Entry informationi

Entry nameiPNP_BORAP
AccessioniPrimary (citable) accession number: Q0SM46
Secondary accession number(s): G0IRY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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