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Q0SJD4

- ACDH1_RHOSR

UniProt

Q0SJD4 - ACDH1_RHOSR

Protein

Acetaldehyde dehydrogenase 1

Gene

RHA1_ro00516

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
    Binding sitei290 – 2901NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi160 – 1689NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-516-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Ordered Locus Names:RHA1_ro00516
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Acetaldehyde dehydrogenase 1PRO_0000387726Add
    BLAST

    Proteomic databases

    PRIDEiQ0SJD4.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro00516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SJD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHARHEQL.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0SJD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTTKVAVIG SGNIGTDLVI KLEQVAKNVE IAVLVGIDPA SDGLARARRL    50
    GISTVDTGVQ GLIEHPEFDD IEIIFDSTSA KAHLTNAEAL RPYGKHLIDL 100
    TPAAIGPYVV PAVNLDQHLG APDVNMVTCG GQATIPIVAA ISKVTDVHYA 150
    EIVASIASKS AGPGTRANID EFTETTAKAI EEVGGAAHGK AIIVLNPADP 200
    PLIMRDTVLA LVSNPDQDAI RQSITDMVAT VAAYVPGYRL KQDVQFTELG 250
    GADTVATLTG GADIGSPVWK VSVFLEVEGA AHYLPAYAGN LDIMTSAALQ 300
    VAEKLAERTA LEIAR 315
    Length:315
    Mass (Da):32,789
    Last modified:September 5, 2006 - v1
    Checksum:i19228CD8EC1EE41A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG92352.1.
    RefSeqiYP_700510.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG92352; ABG92352; RHA1_ro00516.
    GeneIDi4218678.
    KEGGirha:RHA1_ro00516.
    PATRICi23199841. VBIRhoJos26306_0546.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG92352.1 .
    RefSeqi YP_700510.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0SJD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro00516.

    Proteomic databases

    PRIDEi Q0SJD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG92352 ; ABG92352 ; RHA1_ro00516 .
    GeneIDi 4218678.
    KEGGi rha:RHA1_ro00516.
    PATRICi 23199841. VBIRhoJos26306_0546.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HARHEQL.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci RJOS101510:GJJ1-516-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiACDH1_RHOSR
    AccessioniPrimary (citable) accession number: Q0SJD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3