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Protein

Acetaldehyde dehydrogenase 1

Gene

RHA1_ro00516

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Acyl-thioester intermediateUniRule annotation1
Binding sitei290NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADUniRule annotation4
Nucleotide bindingi160 – 168NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:RHA1_ro00516
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877261 – 315Acetaldehyde dehydrogenase 1Add BLAST315

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00516

Structurei

3D structure databases

ProteinModelPortaliQ0SJD4
SMRiQ0SJD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiIMMHNTI
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q0SJD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTKVAVIG SGNIGTDLVI KLEQVAKNVE IAVLVGIDPA SDGLARARRL
60 70 80 90 100
GISTVDTGVQ GLIEHPEFDD IEIIFDSTSA KAHLTNAEAL RPYGKHLIDL
110 120 130 140 150
TPAAIGPYVV PAVNLDQHLG APDVNMVTCG GQATIPIVAA ISKVTDVHYA
160 170 180 190 200
EIVASIASKS AGPGTRANID EFTETTAKAI EEVGGAAHGK AIIVLNPADP
210 220 230 240 250
PLIMRDTVLA LVSNPDQDAI RQSITDMVAT VAAYVPGYRL KQDVQFTELG
260 270 280 290 300
GADTVATLTG GADIGSPVWK VSVFLEVEGA AHYLPAYAGN LDIMTSAALQ
310
VAEKLAERTA LEIAR
Length:315
Mass (Da):32,789
Last modified:September 5, 2006 - v1
Checksum:i19228CD8EC1EE41A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA Translation: ABG92352.1
RefSeqiWP_009473124.1, NC_008268.1

Genome annotation databases

EnsemblBacteriaiABG92352; ABG92352; RHA1_ro00516
GeneIDi4218678
KEGGirha:RHA1_ro00516

Similar proteinsi

Entry informationi

Entry nameiACDH1_RHOJR
AccessioniPrimary (citable) accession number: Q0SJD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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