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Reviewed, UniProtKB/Swiss-Prot Q0SJD2 (MHPB_RHOSR)

Last modified January 19, 2010. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
    EC=1.13.11.16
Gene names
Name: mhpB
Ordered Locus Names: RHA1_ro00518
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively By similarity. HAMAP MF_01653

Catalytic activity

3-(2,3-dihydroxyphenyl)propanoate + O2 = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. HAMAP MF_01653

2,3-dihydroxicinnamic acid + O2 = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. HAMAP MF_01653

Cofactor

Fe2+ ion By similarity. HAMAP MF_01653

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01653

Subunit structure

Homotetramer By similarity. HAMAP MF_01653

Sequence similarities

Belongs to the ligB/mhpB extradiol dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3143142,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase HAMAP MF_01653
PRO_0000337668

Sites

Active site1151Proton donor By similarity
Active site1791Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0SJD2-1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: FA31D55843964567

FASTA31433,844
        10         20         30         40         50         60 
MPVALCTMSH SPLMGRNDPA QTVIDDVDAA FENARTFIAD FAPDLIVIFA PDHYNGVYYD 

        70         80         90        100        110        120 
LMPPFCIGAA AQSVGDYGTE SGPLNVDRDA AYTVAREVLA SGVDVAFSER MHVDHGFAQA 

       130        140        150        160        170        180 
LQLLVGSITA VPTVPIFINS VAEPLGPVSR VRLLGEAVGR AAANLDKRVL FVGSGGLSHD 

       190        200        210        220        230        240 
PPVPQFATAP TEVKEKLIDG RNPTEAERNA REQRVIDAGR DFAAGVATIA PLNPEWDRNL 

       250        260        270        280        290        300 
LDVLTSGEIE QIDSWTNEWF VEQAGHSSHE VRTWIAAYAA MSAAGKYRVT STFYREIPEW 

       310 
IAGFGISTAV AVDE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000431 Genomic DNA. Translation: ABG92354.1.
RefSeqYP_700512.1.

3D structure databases

SMRQ0SJD2. Positions 5-307.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SJD2.

Genome annotation databases

GeneID4218680.
GenomeReviewsGene locus RHA1_ro00518 in contig CP000431_GR.
KEGGrha:RHA1_ro00518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG42398.
HOGENOMHBG565586.
OMAPLNPEWD.

Enzyme and pathway databases

BioCycRSP101510:RHA1_RO00518-MONOMER.

Family and domain databases

HAMAPMF_01653. MhpB.
[Tree]
InterProIPR004183. Xdiol_dOase_3B.
[Graphical view]
PfamPF02900. LigB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMHPB_RHOSR
AccessionPrimary (citable) accession number: Q0SJD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: January 19, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents