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Protein
Submitted name:

Isocitrate dehydrogenase (NADP+)

Gene

RHA1_ro00618

Organism
Rhodococcus jostii (strain RHA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148SubstrateUniRule annotation1
Sitei258Critical for catalysisUniRule annotation1
Metal bindingi353Magnesium or manganeseUniRule annotation1
Sitei423Critical for catalysisUniRule annotation1
Binding sitei551SubstrateUniRule annotation1
Metal bindingi552Magnesium or manganeseUniRule annotation1
Metal bindingi556Magnesium or manganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-618-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:RHA1_ro00618Imported
OrganismiRhodococcus jostii (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ0SJ33.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00618.

Structurei

3D structure databases

ProteinModelPortaliQ0SJ33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 142Substrate bindingUniRule annotation8

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiPOG091H0B3N.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SJ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADKHPTII YTLTDEAPLL ATYAFLPIVR TFAGAAGIEV ESSDISVPAR
60 70 80 90 100
ILAEFPDRLT EEQRVPDNLA ELGRLTQLPE TNIIKLPNIS ASVPQLLAAI
110 120 130 140 150
KELQGKGYQI PDFPEAPKTD EERDIRQRYG RILGSAVNPV LREGNSDRRA
160 170 180 190 200
PRAVKEYVRK HPHSMGEWSM ASRSHVAHMR HGDFYHGEKS MTLDRQRTVR
210 220 230 240 250
MELVTKSGET IVLKEGLALG EGDIMDSMFM SKKALLDFYE EQMEDARKTG
260 270 280 290 300
VMFSLHVKAT MMKVSHPIVF GHAVKTFYKD AFAKHQKLFD ELGVNVNNGL
310 320 330 340 350
VDLYDKIETL PSTQREEIIQ DLHDCHEHRP ELAMVDSARG ISNFHSPSDV
360 370 380 390 400
IVDASMPAMI RSGGMMYGAD GRLKDAKAVM PESTFARIYQ EIINFCKTNG
410 420 430 440 450
AFDPTTMGTV PNVGLMAQKA EEYGSHDKTF EIPEDGDANF VDVETGEVLL
460 470 480 490 500
TQQVEAGDIW RMCTVKDAPI RDWVKLAVTR ARNSGMPVLF WLDPYRPHEN
510 520 530 540 550
ELIKKVELYL QDHDTEGLDI QIMSQVRSMR YTLERLIRGM DTIAATGNIL
560 570 580 590 600
RDYLTDLFPI LELGTSAKML SIVPLMAGGG MYETGAGGSA PKHVKQLVEE
610 620 630 640 650
NHLRWDSLGE FLALAVSFED LGIKTGNEHA KILAKTLDAA TGKLLDENKN
660 670 680 690 700
PSRKTGELDN RGSQFYLALY WAQELAAQTE DKELAERFAT LAEALTENEE
710 720 730 740
TIVRELIEVQ GSPVDIGGYY QPDSEKADAV MRPSKTLNTT LAAAQQ
Length:746
Mass (Da):83,219
Last modified:September 5, 2006 - v1
Checksum:iDBD60BBCE20F208B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1.
RefSeqiWP_009473244.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618.
GeneIDi4219534.
KEGGirha:RHA1_ro00618.
PATRICi23200037. VBIRhoJos26306_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1.
RefSeqiWP_009473244.1. NC_008268.1.

3D structure databases

ProteinModelPortaliQ0SJ33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi101510.RHA1_ro00618.

Proteomic databases

PRIDEiQ0SJ33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618.
GeneIDi4219534.
KEGGirha:RHA1_ro00618.
PATRICi23200037. VBIRhoJos26306_0644.

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.
OrthoDBiPOG091H0B3N.

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-618-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ0SJ33_RHOJR
AccessioniPrimary (citable) accession number: Q0SJ33
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.