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Q0SJ33

- Q0SJ33_RHOSR

UniProt

Q0SJ33 - Q0SJ33_RHOSR

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Protein
Submitted name:

Isocitrate dehydrogenase (NADP+)

Gene

RHA1_ro00618

Organism
Rhodococcus sp. (strain RHA1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481SubstrateUniRule annotation
Sitei258 – 2581Critical for catalysisUniRule annotation
Metal bindingi353 – 3531Magnesium or manganese
Sitei423 – 4231Critical for catalysisUniRule annotation
Binding sitei551 – 5511SubstrateUniRule annotation
Metal bindingi552 – 5521Magnesium or manganese
Metal bindingi556 – 5561Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-618-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:RHA1_ro00618Imported
OrganismiRhodococcus sp. (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ0SJ33.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00618.

Structurei

3D structure databases

ProteinModelPortaliQ0SJ33.
SMRiQ0SJ33. Positions 7-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1428Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SJ33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSADKHPTII YTLTDEAPLL ATYAFLPIVR TFAGAAGIEV ESSDISVPAR
60 70 80 90 100
ILAEFPDRLT EEQRVPDNLA ELGRLTQLPE TNIIKLPNIS ASVPQLLAAI
110 120 130 140 150
KELQGKGYQI PDFPEAPKTD EERDIRQRYG RILGSAVNPV LREGNSDRRA
160 170 180 190 200
PRAVKEYVRK HPHSMGEWSM ASRSHVAHMR HGDFYHGEKS MTLDRQRTVR
210 220 230 240 250
MELVTKSGET IVLKEGLALG EGDIMDSMFM SKKALLDFYE EQMEDARKTG
260 270 280 290 300
VMFSLHVKAT MMKVSHPIVF GHAVKTFYKD AFAKHQKLFD ELGVNVNNGL
310 320 330 340 350
VDLYDKIETL PSTQREEIIQ DLHDCHEHRP ELAMVDSARG ISNFHSPSDV
360 370 380 390 400
IVDASMPAMI RSGGMMYGAD GRLKDAKAVM PESTFARIYQ EIINFCKTNG
410 420 430 440 450
AFDPTTMGTV PNVGLMAQKA EEYGSHDKTF EIPEDGDANF VDVETGEVLL
460 470 480 490 500
TQQVEAGDIW RMCTVKDAPI RDWVKLAVTR ARNSGMPVLF WLDPYRPHEN
510 520 530 540 550
ELIKKVELYL QDHDTEGLDI QIMSQVRSMR YTLERLIRGM DTIAATGNIL
560 570 580 590 600
RDYLTDLFPI LELGTSAKML SIVPLMAGGG MYETGAGGSA PKHVKQLVEE
610 620 630 640 650
NHLRWDSLGE FLALAVSFED LGIKTGNEHA KILAKTLDAA TGKLLDENKN
660 670 680 690 700
PSRKTGELDN RGSQFYLALY WAQELAAQTE DKELAERFAT LAEALTENEE
710 720 730 740
TIVRELIEVQ GSPVDIGGYY QPDSEKADAV MRPSKTLNTT LAAAQQ
Length:746
Mass (Da):83,219
Last modified:September 5, 2006 - v1
Checksum:iDBD60BBCE20F208B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1.
RefSeqiYP_700611.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618.
GeneIDi4219534.
KEGGirha:RHA1_ro00618.
PATRICi23200037. VBIRhoJos26306_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1 .
RefSeqi YP_700611.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0SJ33.
SMRi Q0SJ33. Positions 7-742.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro00618.

Proteomic databases

PRIDEi Q0SJ33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG92453 ; ABG92453 ; RHA1_ro00618 .
GeneIDi 4219534.
KEGGi rha:RHA1_ro00618.
PATRICi 23200037. VBIRhoJos26306_0644.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-618-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1Imported.

Entry informationi

Entry nameiQ0SJ33_RHOSR
AccessioniPrimary (citable) accession number: Q0SJ33
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3