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Protein
Submitted name:

Isocitrate dehydrogenase (NADP+)

Gene

RHA1_ro00618

Organism
Rhodococcus jostii (strain RHA1)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148SubstrateUniRule annotation1
Sitei258Critical for catalysisUniRule annotation1
Metal bindingi353Magnesium or manganeseUniRule annotation1
Sitei423Critical for catalysisUniRule annotation1
Binding sitei551SubstrateUniRule annotation1
Metal bindingi552Magnesium or manganeseUniRule annotation1
Metal bindingi556Magnesium or manganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:RHA1_ro00618Imported
OrganismiRhodococcus jostii (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000008710 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00618

Structurei

3D structure databases

ProteinModelPortaliQ0SJ33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 142Substrate bindingUniRule annotation8

Phylogenomic databases

eggNOGiENOG4105E9K Bacteria
COG2838 LUCA
HOGENOMiHOG000240860
KOiK00031
OMAiRDSGKMW
OrthoDBiPOG091H0B3N

Family and domain databases

InterProiView protein in InterPro
IPR004436 Isocitrate_DH_NADP_mono
PANTHERiPTHR36999 PTHR36999, 1 hit
PfamiView protein in Pfam
PF03971 IDH, 1 hit
PIRSFiPIRSF009407 IDH_monmr, 1 hit
TIGRFAMsiTIGR00178 monomer_idh, 1 hit

Sequencei

Sequence statusi: Complete.

Q0SJ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADKHPTII YTLTDEAPLL ATYAFLPIVR TFAGAAGIEV ESSDISVPAR
60 70 80 90 100
ILAEFPDRLT EEQRVPDNLA ELGRLTQLPE TNIIKLPNIS ASVPQLLAAI
110 120 130 140 150
KELQGKGYQI PDFPEAPKTD EERDIRQRYG RILGSAVNPV LREGNSDRRA
160 170 180 190 200
PRAVKEYVRK HPHSMGEWSM ASRSHVAHMR HGDFYHGEKS MTLDRQRTVR
210 220 230 240 250
MELVTKSGET IVLKEGLALG EGDIMDSMFM SKKALLDFYE EQMEDARKTG
260 270 280 290 300
VMFSLHVKAT MMKVSHPIVF GHAVKTFYKD AFAKHQKLFD ELGVNVNNGL
310 320 330 340 350
VDLYDKIETL PSTQREEIIQ DLHDCHEHRP ELAMVDSARG ISNFHSPSDV
360 370 380 390 400
IVDASMPAMI RSGGMMYGAD GRLKDAKAVM PESTFARIYQ EIINFCKTNG
410 420 430 440 450
AFDPTTMGTV PNVGLMAQKA EEYGSHDKTF EIPEDGDANF VDVETGEVLL
460 470 480 490 500
TQQVEAGDIW RMCTVKDAPI RDWVKLAVTR ARNSGMPVLF WLDPYRPHEN
510 520 530 540 550
ELIKKVELYL QDHDTEGLDI QIMSQVRSMR YTLERLIRGM DTIAATGNIL
560 570 580 590 600
RDYLTDLFPI LELGTSAKML SIVPLMAGGG MYETGAGGSA PKHVKQLVEE
610 620 630 640 650
NHLRWDSLGE FLALAVSFED LGIKTGNEHA KILAKTLDAA TGKLLDENKN
660 670 680 690 700
PSRKTGELDN RGSQFYLALY WAQELAAQTE DKELAERFAT LAEALTENEE
710 720 730 740
TIVRELIEVQ GSPVDIGGYY QPDSEKADAV MRPSKTLNTT LAAAQQ
Length:746
Mass (Da):83,219
Last modified:September 5, 2006 - v1
Checksum:iDBD60BBCE20F208B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA Translation: ABG92453.1
RefSeqiWP_009473244.1, NC_008268.1

Genome annotation databases

EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618
GeneIDi4219534
KEGGirha:RHA1_ro00618
PATRICifig|101510.16.peg.644

Similar proteinsi

Entry informationi

Entry nameiQ0SJ33_RHOJR
AccessioniPrimary (citable) accession number: Q0SJ33
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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