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Q0SJ33

- Q0SJ33_RHOSR

UniProt

Q0SJ33 - Q0SJ33_RHOSR

Protein
Submitted name:

Isocitrate dehydrogenase (NADP+)

Gene

RHA1_ro00618

Organism
Rhodococcus sp. (strain RHA1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei148 – 1481SubstrateUniRule annotation
    Sitei258 – 2581Critical for catalysisUniRule annotation
    Metal bindingi353 – 3531Magnesium or manganese
    Sitei423 – 4231Critical for catalysisUniRule annotation
    Binding sitei551 – 5511SubstrateUniRule annotation
    Metal bindingi552 – 5521Magnesium or manganese
    Metal bindingi556 – 5561Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-618-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:RHA1_ro00618Imported
    OrganismiRhodococcus sp. (strain RHA1)Imported
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiQ0SJ33.

    Interactioni

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro00618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SJ33.
    SMRiQ0SJ33. Positions 7-742.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1428Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0SJ33-1 [UniParc]FASTAAdd to Basket

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    MSADKHPTII YTLTDEAPLL ATYAFLPIVR TFAGAAGIEV ESSDISVPAR    50
    ILAEFPDRLT EEQRVPDNLA ELGRLTQLPE TNIIKLPNIS ASVPQLLAAI 100
    KELQGKGYQI PDFPEAPKTD EERDIRQRYG RILGSAVNPV LREGNSDRRA 150
    PRAVKEYVRK HPHSMGEWSM ASRSHVAHMR HGDFYHGEKS MTLDRQRTVR 200
    MELVTKSGET IVLKEGLALG EGDIMDSMFM SKKALLDFYE EQMEDARKTG 250
    VMFSLHVKAT MMKVSHPIVF GHAVKTFYKD AFAKHQKLFD ELGVNVNNGL 300
    VDLYDKIETL PSTQREEIIQ DLHDCHEHRP ELAMVDSARG ISNFHSPSDV 350
    IVDASMPAMI RSGGMMYGAD GRLKDAKAVM PESTFARIYQ EIINFCKTNG 400
    AFDPTTMGTV PNVGLMAQKA EEYGSHDKTF EIPEDGDANF VDVETGEVLL 450
    TQQVEAGDIW RMCTVKDAPI RDWVKLAVTR ARNSGMPVLF WLDPYRPHEN 500
    ELIKKVELYL QDHDTEGLDI QIMSQVRSMR YTLERLIRGM DTIAATGNIL 550
    RDYLTDLFPI LELGTSAKML SIVPLMAGGG MYETGAGGSA PKHVKQLVEE 600
    NHLRWDSLGE FLALAVSFED LGIKTGNEHA KILAKTLDAA TGKLLDENKN 650
    PSRKTGELDN RGSQFYLALY WAQELAAQTE DKELAERFAT LAEALTENEE 700
    TIVRELIEVQ GSPVDIGGYY QPDSEKADAV MRPSKTLNTT LAAAQQ 746
    Length:746
    Mass (Da):83,219
    Last modified:September 5, 2006 - v1
    Checksum:iDBD60BBCE20F208B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG92453.1.
    RefSeqiYP_700611.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618.
    GeneIDi4219534.
    KEGGirha:RHA1_ro00618.
    PATRICi23200037. VBIRhoJos26306_0644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG92453.1 .
    RefSeqi YP_700611.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0SJ33.
    SMRi Q0SJ33. Positions 7-742.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro00618.

    Proteomic databases

    PRIDEi Q0SJ33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG92453 ; ABG92453 ; RHA1_ro00618 .
    GeneIDi 4219534.
    KEGGi rha:RHA1_ro00618.
    PATRICi 23200037. VBIRhoJos26306_0644.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci RJOS101510:GJJ1-618-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1Imported.

    Entry informationi

    Entry nameiQ0SJ33_RHOSR
    AccessioniPrimary (citable) accession number: Q0SJ33
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3