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Q0SJ33

- Q0SJ33_RHOSR

UniProt

Q0SJ33 - Q0SJ33_RHOSR

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Protein
Submitted name: Isocitrate dehydrogenase (NADP+)
Gene
RHA1_ro00618
Organism
Rhodococcus sp. (strain RHA1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481Substrate By similarity
Sitei258 – 2581Critical for catalysis By similarityUniRule annotation
Metal bindingi353 – 3531Magnesium or manganese By similarityUniRule annotation
Sitei423 – 4231Critical for catalysis By similarityUniRule annotation
Binding sitei551 – 5511Substrate By similarityUniRule annotation
Metal bindingi552 – 5521Magnesium or manganese By similarityUniRule annotation
Metal bindingi556 – 5561Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-618-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:RHA1_ro00618Imported
OrganismiRhodococcus sp. (strain RHA1)Imported
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ0SJ33.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00618.

Structurei

3D structure databases

ProteinModelPortaliQ0SJ33.
SMRiQ0SJ33. Positions 7-742.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1428Substrate binding By similarity

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SJ33-1 [UniParc]FASTAAdd to Basket

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MSADKHPTII YTLTDEAPLL ATYAFLPIVR TFAGAAGIEV ESSDISVPAR    50
ILAEFPDRLT EEQRVPDNLA ELGRLTQLPE TNIIKLPNIS ASVPQLLAAI 100
KELQGKGYQI PDFPEAPKTD EERDIRQRYG RILGSAVNPV LREGNSDRRA 150
PRAVKEYVRK HPHSMGEWSM ASRSHVAHMR HGDFYHGEKS MTLDRQRTVR 200
MELVTKSGET IVLKEGLALG EGDIMDSMFM SKKALLDFYE EQMEDARKTG 250
VMFSLHVKAT MMKVSHPIVF GHAVKTFYKD AFAKHQKLFD ELGVNVNNGL 300
VDLYDKIETL PSTQREEIIQ DLHDCHEHRP ELAMVDSARG ISNFHSPSDV 350
IVDASMPAMI RSGGMMYGAD GRLKDAKAVM PESTFARIYQ EIINFCKTNG 400
AFDPTTMGTV PNVGLMAQKA EEYGSHDKTF EIPEDGDANF VDVETGEVLL 450
TQQVEAGDIW RMCTVKDAPI RDWVKLAVTR ARNSGMPVLF WLDPYRPHEN 500
ELIKKVELYL QDHDTEGLDI QIMSQVRSMR YTLERLIRGM DTIAATGNIL 550
RDYLTDLFPI LELGTSAKML SIVPLMAGGG MYETGAGGSA PKHVKQLVEE 600
NHLRWDSLGE FLALAVSFED LGIKTGNEHA KILAKTLDAA TGKLLDENKN 650
PSRKTGELDN RGSQFYLALY WAQELAAQTE DKELAERFAT LAEALTENEE 700
TIVRELIEVQ GSPVDIGGYY QPDSEKADAV MRPSKTLNTT LAAAQQ 746
Length:746
Mass (Da):83,219
Last modified:September 5, 2006 - v1
Checksum:iDBD60BBCE20F208B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1.
RefSeqiYP_700611.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG92453; ABG92453; RHA1_ro00618.
GeneIDi4219534.
KEGGirha:RHA1_ro00618.
PATRICi23200037. VBIRhoJos26306_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92453.1 .
RefSeqi YP_700611.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0SJ33.
SMRi Q0SJ33. Positions 7-742.
ModBasei Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro00618.

Proteomic databases

PRIDEi Q0SJ33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG92453 ; ABG92453 ; RHA1_ro00618 .
GeneIDi 4219534.
KEGGi rha:RHA1_ro00618.
PATRICi 23200037. VBIRhoJos26306_0644.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-618-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiQ0SJ33_RHOSR
AccessioniPrimary (citable) accession number: Q0SJ33
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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