Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0SIC2 (UPPP_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:RHA1_ro00881
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250254

Regions

Transmembrane89 – 10921Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane258 – 27821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0SIC2 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 85E64E031A41C960

FASTA28130,045
        10         20         30         40         50         60 
MGEAMSWLQA IVLGTVQGLT EFLPISSSGH LRIVSEVFFG DDAGASFTAV TQLGTEAAVL 

        70         80         90        100        110        120 
IYFARDIGRI IAGWFRGLFH PEHRGDLDYR MGWYVIIGTI PVGVLGFLFK DQIRTGARNL 

       130        140        150        160        170        180 
WLIATMLIVF ALVIAAAEYY GRKVRPVEDL RAKDGIIMGS AQALALIPGV SRSGGTISAG 

       190        200        210        220        230        240 
LFLGLTREAA ARYSFLLAIP AVVASGLFSL PDAFEPAGEG LNASGPQLLV ATVIAFAIGY 

       250        260        270        280 
ASIAWLLRFV VDHSMYWFVG YRIILGVVVL SLLATGVVSA T 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000431 Genomic DNA. Translation: ABG92714.1.
RefSeqYP_700872.1. NC_008268.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro00881.

Proteomic databases

PRIDEQ0SIC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG92714; ABG92714; RHA1_ro00881.
GeneID4218210.
KEGGrha:RHA1_ro00881.
PATRIC23200551. VBIRhoJos26306_0901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-880-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_RHOSR
AccessionPrimary (citable) accession number: Q0SIC2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families