Q0SI81 (KCY_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	RHA1_ro00924

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Cytidylate kinase HAMAP MF_00238		PRO_1000048263
Regions
	Nucleotide binding	12 – 20	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0SI81 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 15C0BFB732758B6D	FASTA	229	24,066
	10 20 30 40 50 60 MSTSKLVVAM DGPSGTGKSS VSRMLAQRLD ARYLDTGAMY RIATLHALRK GVDLTDPAAI 70 80 90 100 110 120 ADATAGLPWS IGTDPAGEQV LLDGEDVGEE IRGDAVTKAV SAVSAVPAVR ELLVAAQRRL 130 140 150 160 170 180 AGEAERIVVE GRDIGTVVIP DADVKIYLTA SAEARAQRRN AQNLAEGRGD DYAAVLADVQ 190 200 210 220 RRDHLDSTRA VSPLRPADDS VLVDTSELGI DDVIGRLLLV VSERTGAGQ

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RHA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG92755.1.
RefSeq	YP_700913.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SI81.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SI81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4219103.
GenomeReviews	Gene locus RHA1_ro00924 in contig CP000431_GR.
KEGG	rha:RHA1_ro00924.
PATRIC	23200643. VBIRhoJos26306_0945.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HBG354377.
OMA	DIGTVIC.
PhylomeDB	Q0SI81.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO00924-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_RHOSR

Accession

Primary (citable) accession number: Q0SI81

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program