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Q0SI70

- NADK_RHOSR

UniProt

Q0SI70 - NADK_RHOSR

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Protein
NAD kinase
Gene
nadK, RHA1_ro00935
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton acceptor By similarity
Binding sitei101 – 1011NAD By similarity
Binding sitei200 – 2001NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 972NAD By similarity
Nucleotide bindingi170 – 1712NAD By similarity
Nucleotide bindingi211 – 2166NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-934-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:RHA1_ro00935
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320NAD kinaseUniRule annotation
PRO_1000005437Add
BLAST

Proteomic databases

PRIDEiQ0SI70.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro00935.

Structurei

3D structure databases

ProteinModelPortaliQ0SI70.
SMRiQ0SI70. Positions 13-316.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SI70-1 [UniParc]FASTAAdd to Basket

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MSGGSSGTQQ REREILLVAH PGRAEITETA RRVGKIFERA GIGLRVLVDE    50
VDSTRIEPMD GMAADEFLVP GLEVTIVQAG PDAALGCEMV LVLGGDGTFL 100
RAAELAQAAS IPVLGINLGR IGFLAETEAE HLDEALAQVV RREYRIEHRM 150
TLDVLVRVDD EIIERGWALN EASIENRSRL GVLEVVLEVD GRPVSAFGCD 200
GVLISTPTGS TAYAFSAGGP VVWPELEALL VVPSNAHALF ARPLVTSPNS 250
LIAVETVAGS HDGLVFCDGR RTLELPAGAR VEVVRGKEPV RWIRLDSAPF 300
ADRMVRKFEL PVTGWRGRKP 320
Length:320
Mass (Da):34,498
Last modified:September 5, 2006 - v1
Checksum:i4B61C5660E165155
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92766.1.
RefSeqiYP_700924.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG92766; ABG92766; RHA1_ro00935.
GeneIDi4218056.
KEGGirha:RHA1_ro00935.
PATRICi23200665. VBIRhoJos26306_0956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG92766.1 .
RefSeqi YP_700924.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0SI70.
SMRi Q0SI70. Positions 13-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro00935.

Proteomic databases

PRIDEi Q0SI70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG92766 ; ABG92766 ; RHA1_ro00935 .
GeneIDi 4218056.
KEGGi rha:RHA1_ro00935.
PATRICi 23200665. VBIRhoJos26306_0956.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-934-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiNADK_RHOSR
AccessioniPrimary (citable) accession number: Q0SI70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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