Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0SI70 (NADK_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:RHA1_ro00935
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320NAD kinase HAMAP-Rule MF_00361
PRO_1000005437

Regions

Nucleotide binding96 – 972NAD By similarity
Nucleotide binding170 – 1712NAD By similarity
Nucleotide binding211 – 2166NAD By similarity

Sites

Active site961Proton acceptor By similarity
Binding site1011NAD By similarity
Binding site2001NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0SI70 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 4B61C5660E165155

FASTA32034,498
        10         20         30         40         50         60 
MSGGSSGTQQ REREILLVAH PGRAEITETA RRVGKIFERA GIGLRVLVDE VDSTRIEPMD 

        70         80         90        100        110        120 
GMAADEFLVP GLEVTIVQAG PDAALGCEMV LVLGGDGTFL RAAELAQAAS IPVLGINLGR 

       130        140        150        160        170        180 
IGFLAETEAE HLDEALAQVV RREYRIEHRM TLDVLVRVDD EIIERGWALN EASIENRSRL 

       190        200        210        220        230        240 
GVLEVVLEVD GRPVSAFGCD GVLISTPTGS TAYAFSAGGP VVWPELEALL VVPSNAHALF 

       250        260        270        280        290        300 
ARPLVTSPNS LIAVETVAGS HDGLVFCDGR RTLELPAGAR VEVVRGKEPV RWIRLDSAPF 

       310        320 
ADRMVRKFEL PVTGWRGRKP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000431 Genomic DNA. Translation: ABG92766.1.
RefSeqYP_700924.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0SI70.
SMRQ0SI70. Positions 13-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro00935.

Proteomic databases

PRIDEQ0SI70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG92766; ABG92766; RHA1_ro00935.
GeneID4218056.
KEGGrha:RHA1_ro00935.
PATRIC23200665. VBIRhoJos26306_0956.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227223.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-934-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_RHOSR
AccessionPrimary (citable) accession number: Q0SI70
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families