Q0SH20 (Q0SH20_RHOSR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE1 EMBL ABG93166.1
Synonyms:	aroE HAMAP MF_00222
Ordered Locus Names:	RHA1_ro01342

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG93166.1

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ABG93166.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	143 – 147	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	83	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q0SH20 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 6924126D6A1E0D70	FASTA	304	31,662
	10 20 30 40 50 60 MTSRDLDAPT ARPSYLCGLI GTGISKSLTP PLHEAEGRAQ GVGYVYRILD LDTLGMGVEG 70 80 90 100 110 120 LPQLLSAAKL LGFNGLNITH PCKQAVIPLL DDLSDDARKL GAVNTVHIEG GRLIGHNTDW 130 140 150 160 170 180 SGFARNMDEG LEGAPMNHVV QLGAGGAGAA VAYAALTRGV GHFTIIDADA ARSKDLRDSL 190 200 210 220 230 240 AELFPDREIA AGDLSAVPAA VGAAQGLIHA TPIGMAAHPG MALDAALLRP DLWVADVVYR 250 260 270 280 290 300 PAETELLARA REIGARTLSG IGMTIGQAVD SFRIFTGLEP DAQRMREHMG LLLQAEDAAA LAGA

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG93166.1.
RefSeq	YP_701324.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SH20.
SMR	Q0SH20. Positions 14-289.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SH20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4219679.
GenomeReviews	Gene locus RHA1_ro01342 in contig CP000431_GR.
KEGG	rha:RHA1_ro01342.
PATRIC	23201507. VBIRhoJos26306_1370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	HEHEGDA.
PhylomeDB	Q0SH20.
ProtClustDB	PRK12549.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO01342-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0SH20_RHOSR

Accession

Primary (citable) accession number: Q0SH20

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)