Reviewed, UniProtKB/Swiss-Prot Q0SH07 (IOLG_RHOSR)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RHA1_ro01355

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352588

Sequences

	Sequence		Length	Mass (Da)
	Q0SH07-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 0AF723DDFA589E2A	FASTA	366	38,830
	10 20 30 40 50 60 MSGSNDLRIA VLGVGMMGAD HVARITERIK GATVAVVNDY FIEKAEQIAA GIPGCRVIGD 70 80 90 100 110 120 PLDAIADPDV DAVVLATPGP THEKQLLACL EHGKPVMCEK PLTTDVATSL EIVKREAELG 130 140 150 160 170 180 KKLIQVGFMR RFDHEYEQLK TLIDDGTFGQ VLLAHCVHRN PAVPPSFDSS MIVKDSLVHE 190 200 210 220 230 240 VDVTRFLFDE EITSVHILRP AANPGAPEGL QDPQIALFST ESGRHVDVEV FVTTGVAYEV 250 260 270 280 290 300 RTEIVAEKGS AFIGLDVGLV RKFGTGAGNG RSGAGMSGGE ITPSFKERFG QAYDVEIQRW 310 320 330 340 350 360 VNAARTGAET GNYIDGPGAW DGYAAAAVCA AGVQSLETGE RVAVDMVDRS SIPGAEPAER PIGPGA

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000431 Genomic DNA. Translation: ABG93179.1.
RefSeq	YP_701337.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SH07.
Genome annotation databases
GeneID	4219692.
GenomeReviews	Gene locus RHA1_ro01355 in contig CP000431_GR.
KEGG	rha:RHA1_ro01355.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SH07.
OMA	YAAAAVC.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RHOSR

Accession

Primary (citable) accession number: Q0SH07

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	September 5, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)