Q0SGN5 (Q0SGN5_RHOSR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384

Gene names

Name:	thrB HAMAP MF_00384
Ordered Locus Names:	RHA1_ro01486

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG93301.1

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm By similarity HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis HAMAP MF_00384
Cellular component	Cytoplasm HAMAP MF_00384
Ligand	ATP-binding HAMAP MF_00384 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00384 EMBL ABG93301.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	110 – 120	11	ATP By similarity HAMAP MF_00384

Sequences

	Sequence		Length	Mass (Da)
	Q0SGN5 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 7834ECA8FA297003	FASTA	329	33,711
	10 20 30 40 50 60 MVAPTPTTPQ DHTAAMTQTL PTGLTVTARV PASSANLGPG FDTLGIALGL YDEITVTTTG 70 80 90 100 110 120 SGLKIRVEGE GADDVPWGPS HLVVRAIERG LESAGVWADG LDVVCRNAIP HSRGLGSSAS 130 140 150 160 170 180 AVVGGLAAAN GLAIKLDPEL GLSLDQLVQL SSEFEGHPDN ASASVLGGAV VSWSCASEQP 190 200 210 220 230 240 DGAPAATDIY SAVALKVHPA IRVVALVPGE RSSTAHTRGL LPETVPHRDA AFNVSRGALA 250 260 270 280 290 300 VVALTERPDL LMAATEDRLH QTQRAPALPL TTRWIAVLRK AGIAATVSGA GPTVLALTTE 310 320 PFPVDLRAQA EAEGLQVLEL DVADGVRTS

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG93301.1.
RefSeq	YP_701459.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SGN5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SGN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4218864.
GenomeReviews	Gene locus RHA1_ro01486 in contig CP000431_GR.
KEGG	rha:RHA1_ro01486.
PATRIC	23201795. VBIRhoJos26306_1505.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0083.
HOGENOM	HBG646290.
OMA	DRLHQPY.
PhylomeDB	Q0SGN5.
ProtClustDB	PRK01212.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO01486-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0SGN5_RHOSR

Accession

Primary (citable) accession number: Q0SGN5

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)