Q0SGN1 (SYR_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	RHA1_ro01490

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000018103
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q0SGN1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: DC3C0CEC0E8A2A2A	FASTA	550	59,199
	10 20 30 40 50 60 MTPADLAELL RGTAAKVLDE RGLDVSVLPE TLTVERPRNP EHGDYATNVA MQVAKKVGTN 70 80 90 100 110 120 PRELAGWLAE ALTAAEGIDS ADIAGPGFLN IRLAADAQGA IVAKILDEGA AFGSGHTLDG 130 140 150 160 170 180 KRINLEFVSA NPTGPIHLGG TRWAAVGDAL GRILSTQGAA VTREYYFNDH GAQIDRFSRS 190 200 210 220 230 240 LIAAAKGEPA PEDGYAGAYI ADIAAQVQSQ RPDVLELPAG EQQEVFRAIG VDLMFAHIKR 250 260 270 280 290 300 TLHEFGVDFD VYFHENSLFE SGAVEKAVET LKDSGNLFQE DGAWWLKSTD FGDDKDRVVI 310 320 330 340 350 360 KSDGNAAYIA GDIAYFQDKR SRGFDLCIYM LGADHHGYIG RLKAAAAAFG DDPDTVEVLI 370 380 390 400 410 420 GQMVNLVRDG VAVKMSKRAG TVITLDDLVE AIGVDASRYA MIRSSVDSSI DIDLELWTST 430 440 450 460 470 480 GNENPVYYVQ YAHARLSAIA RNAADLGIAV ADPDFSLLVS EQEGDLIRTL GEYPRVVTSA 490 500 510 520 530 540 ANLREPHRIA RYLEELAGAY HRFYGACRIL PQGDEEVGPL HIARLALCDA SRQVLSNGLA 550 LLGVSAPEQM

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RHA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG93305.1.
RefSeq	YP_701463.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SGN1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SGN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4218868.
GenomeReviews	Gene locus RHA1_ro01490 in contig CP000431_GR.
KEGG	rha:RHA1_ro01490.
PATRIC	23201803. VBIRhoJos26306_1509.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HBG695395.
OMA	FDVYFHE.
PhylomeDB	Q0SGN1.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO01490-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_RHOSR

Accession

Primary (citable) accession number: Q0SGN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program