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Q0SFS3 (Q0SFS3_RHOSR) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
Ordered Locus Names:RHA1_ro01800
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG93613.1
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
Q0SFS3 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 88D67A1558E7D8C5

FASTA41144,311
        10         20         30         40         50         60 
MMTTSTDVPA ARAAELDAAD PLRPYRDLFI GADDPSVPAY LDGNSLGRPT KASAERINAF 

        70         80         90        100        110        120 
VTQSWGGRLI RGWDEEWYDL PITIGDTLAR VSLGAAAGQT TIGDSTTVLL YKLARGALAL 

       130        140        150        160        170        180 
RPDRTEIVVD RDNFPTDRYV LEAVAGELGL TLRWIESDTR GGVTVDDLTS VVSERTALVV 

       190        200        210        220        230        240 
LSHVAYRSGY LVDAAGAARV THDAGALLLL DLCHSVGSVP LELDTWGVDL AVGCTYKYLN 

       250        260        270        280        290        300 
GGPGSPAFAY VRADHQQDFV QPIWGWMGRD NPFAMEQGYR PAPGIRRVIS GTPSVLGMIA 

       310        320        330        340        350        360 
LQDTLALLDE VGMDAVRAKS IALTEYALDL VREVLIPLGV EIGSPEDSAE RGGHVIIDHP 

       370        380        390        400        410 
RFQTVVERLW TKGVIPDFRA PQGLRLGLSP LSTSFGEVFA GILAIRDELT D

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000431 Genomic DNA. Translation: ABG93613.1.
RefSeqYP_701771.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0SFS3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SFS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4218731.
GenomeReviewsGene locus RHA1_ro01800 in contig CP000431_GR.
KEGGrha:RHA1_ro01800.
PATRIC23202427. VBIRhoJos26306_1819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHBG523016.
OMAGSPAFAY.
PhylomeDBQ0SFS3.
ProtClustDBCLSK956672.

Enzyme and pathway databases

BioCycRSP101510:RHA1_RO01800-MONOMER.

Family and domain databases

InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK01556.
PANTHERPTHR14084. Kynureninase. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0SFS3_RHOSR
AccessionPrimary (citable) accession number: Q0SFS3
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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