Q0SF29 (Q0SF29_RHOSR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ABG93857.1
EC=4.2.1.24 EMBL ABG93857.1

Gene names

Ordered Locus Names:

RHA1_ro02050

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG93857.1

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase EMBL ABG93857.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	217	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	269	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	254	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	227	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	238	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	295	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	334	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q0SF29 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 7397610841D036F1	FASTA	343	37,185
	10 20 30 40 50 60 MRSPDTPQPL TGPTKEGMSL FPTHRPRRLR RTPALRRLVA ETSLEPRHLV LPMFVADGID 70 80 90 100 110 120 EPREISSMPG VFQHTPDSLR RAATEAVEAG LGGLMLFGVP RPDDKDAEGS GASDPDGILN 130 140 150 160 170 180 RGLRWLADEV GDATVIMADT CLDEFTDHGH CGVLDESGAV DNDLTLQRYV EMAVAQAEAG 190 200 210 220 230 240 AHLLGPSGMM DGQVAAIRKA LDDADYTDVG QLAYSAKYAS AFYGPFREAV GSSLQGDRRT 250 260 270 280 290 300 YQQDSANRRE SLREVDLDID EGADMVMVKP AMSYLDVLRE TADRSPVPVA AYQISGEYSM 310 320 330 340 ITAAAQNGWI DRDAAILESL TSIRRAGADV VLTYWATEAA GWL

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG93857.1.
RefSeq	YP_702015.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SF29.
SMR	Q0SF29. Positions 24-343.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SF29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4218096.
GenomeReviews	Gene locus RHA1_ro02050 in contig CP000431_GR.
KEGG	rha:RHA1_ro02050.
PATRIC	23202947. VBIRhoJos26306_2075.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	FTSHGHD.
PhylomeDB	Q0SF29.
ProtClustDB	PRK09283.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO02050-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0SF29_RHOSR

Accession

Primary (citable) accession number: Q0SF29

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)