Q0SES0 (PSD_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	RHA1_ro02159

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.
Sequence caution	The sequence ABG93966.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000262255
	Chain	206 – 237	32	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000262256
Sites
	Site	205 – 206	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	206	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0SES0 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 387EB7775513EB5A	FASTA	237	25,037
	10 20 30 40 50 60 MARKPTPPGT QQPTSVGHIL DLVRGAVPPL HPAGLPFVLA PLGVAVLGRK RKWVRRGALT 70 80 90 100 110 120 SAAACAAFFR HPHRVPPNRV GVVVAPADGE VALVDSAVPP AELDMGTEPL PRVSIFLSVL 130 140 150 160 170 180 DVHVQRSPVG GEVTKVVHRP GQFLSADLAD ASEVNERNSM LLHTPEGHDV AVVQIAGLLA 190 200 210 220 230 RRIVCDAKVG DTLPIGDTYG LIRFGSRVDT YFPAGTTLLA ERGQRTIGAE TVIAQLP

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RHA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG93966.1. Different initiation.
RefSeq	YP_702124.1. NC_008268.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SES0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4217903.
GenomeReviews	Gene locus RHA1_ro02159 in contig CP000431_GR.
KEGG	rha:RHA1_ro02159.
PATRIC	23203167. VBIRhoJos26306_2185.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0688.
HOGENOM	HBG541103.
OMA	IFMSVFN.
ProtClustDB	PRK05305.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO02159-MONOMER.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_RHOSR

Accession

Primary (citable) accession number: Q0SES0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program