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Q0SEI1

- TYSY_RHOSR

UniProt

Q0SEI1 - TYSY_RHOSR

Protein

Thymidylate synthase

Gene

thyA

Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciRJOS101510:GJJ1-2246-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:RHA1_ro02248
    OrganismiRhodococcus sp. (strain RHA1)
    Taxonomic identifieri101510 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000008710: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Thymidylate synthasePRO_1000000662Add
    BLAST

    Proteomic databases

    PRIDEiQ0SEI1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi101510.RHA1_ro02248.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SEI1.
    SMRiQ0SEI1. Positions 7-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 2 hits.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0SEI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVPTPYEDL LRLVMDTGTP KADRTGTGTK SVFGHQMRWN LADGFPLITT    50
    KKVHLKSIVY ELLWFLRGDS NVKWLQDNGV TIWDEWADAD GELGPVYGVQ 100
    WRSWPTPSGE HIDQITQTIE TLKSNPDSRR IIVSAWNVGD IPQMALAPCH 150
    AFFQFYVADG KLSCQLYQRS ADLFLGVPFN IASYALLTHM VAQQAGLEPG 200
    DFIWTGGDCH IYDNHVDQVT EQLSREPLPY PTLKLNKRES IFDYTFEDVE 250
    IVDYRHHPAI KAPVAV 266
    Length:266
    Mass (Da):30,152
    Last modified:September 5, 2006 - v1
    Checksum:i992DB805E90B99E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG94055.1.
    RefSeqiYP_702213.1. NC_008268.1.

    Genome annotation databases

    EnsemblBacteriaiABG94055; ABG94055; RHA1_ro02248.
    GeneIDi4219800.
    KEGGirha:RHA1_ro02248.
    PATRICi23203349. VBIRhoJos26306_2276.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000431 Genomic DNA. Translation: ABG94055.1 .
    RefSeqi YP_702213.1. NC_008268.1.

    3D structure databases

    ProteinModelPortali Q0SEI1.
    SMRi Q0SEI1. Positions 7-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 101510.RHA1_ro02248.

    Proteomic databases

    PRIDEi Q0SEI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG94055 ; ABG94055 ; RHA1_ro02248 .
    GeneIDi 4219800.
    KEGGi rha:RHA1_ro02248.
    PATRICi 23203349. VBIRhoJos26306_2276.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci RJOS101510:GJJ1-2246-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 2 hits.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RHA1.

    Entry informationi

    Entry nameiTYSY_RHOSR
    AccessioniPrimary (citable) accession number: Q0SEI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3