Q0SCK0 (Q0SCK0_RHOSR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase 2 HAMAP MF_00259
EC=2.1.2.10 HAMAP MF_00259

Alternative name(s):
Glycine cleavage system T protein 2 HAMAP MF_00259

Gene names

Name:	gcvT2 HAMAP MF_00259
Ordered Locus Names:	RHA1_ro02931

Organism

Rhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP] EMBL ABG94736.1

Taxonomic identifier

101510 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the GcvT family. HAMAP MF_00259

Ontologies

Keywords
Molecular function	Aminotransferase HAMAP MF_00259 Methyltransferase EMBL ABG94736.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0SCK0 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 0209AAE217F89E80	FASTA	371	39,179
	10 20 30 40 50 60 MTLTTTPASP LLGEHGALGA HFTDFAGWQM PLKYDSELAE HHAVRKTAGL FDLSHMGEIA 70 80 90 100 110 120 VTGPESGAVL DYALAGELSK IGVGRAKYSL LCNAGGGVID DLVVYRLANE HFLVVANAAN 130 140 150 160 170 180 APTVHRELAA RVEGFSARVD DQSSETALIA VQGPAAQDVV QSLVPAEQVE TVAELKYYAV 190 200 210 220 230 240 TRAVVAGIDV LLARTGYTGE DGFELYVPNE LSVQLWRALL DATTARGGVP AGLACRDTLR 250 260 270 280 290 300 LEAGMALYGH ELTLDTNPYE AGLGKVVRLN KDFVGRDALQ TLSDQAPQRV LVGLAGGGRR 310 320 330 340 350 360 AARAEYTVLD AAGESAVGTI TSGALSPTLG HPIALAFVDV AFREPGTELT VDIRGKKEPF 370 VVTPSPFYRR S

References

[1]

"The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse." McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H. , Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., Eltis L.D. Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006) [PubMed: 17030794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000431 Genomic DNA. Translation: ABG94736.1.
RefSeq	YP_702894.1. NC_008268.1.
3D structure databases
ProteinModelPortal	Q0SCK0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SCK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4220483.
GenomeReviews	Gene locus RHA1_ro02931 in contig CP000431_GR.
KEGG	rha:RHA1_ro02931.
PATRIC	23204721. VBIRhoJos26306_2961.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q0SCK0.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	RSP101510:RHA1_RO02931-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0SCK0_RHOSR

Accession

Primary (citable) accession number: Q0SCK0

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)