ID Q0SCB4_RHOJR Unreviewed; 1035 AA. AC Q0SCB4; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 27-MAR-2024, entry version 135. DE SubName: Full=Protein kinase/ transcriptional regulator, LuxR family protein {ECO:0000313|EMBL:ABG94822.1}; DE EC=2.7.11.1 {ECO:0000313|EMBL:ABG94822.1}; GN OrderedLocusNames=RHA1_ro03019 {ECO:0000313|EMBL:ABG94822.1}; OS Rhodococcus jostii (strain RHA1). OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae; OC Rhodococcus. OX NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG94822.1, ECO:0000313|Proteomes:UP000008710}; RN [1] {ECO:0000313|Proteomes:UP000008710} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710}; RX PubMed=17030794; DOI=10.1073/pnas.0607048103; RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C., RA Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H., RA Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H., RA Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R., RA Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W., RA Eltis L.D.; RT "The complete genome of Rhodococcus sp. RHA1 provides insights into a RT catabolic powerhouse."; RL Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000256|ARBA:ARBA00001433}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000431; ABG94822.1; -; Genomic_DNA. DR AlphaFoldDB; Q0SCB4; -. DR KEGG; rha:RHA1_ro03019; -. DR eggNOG; COG0515; Bacteria. DR eggNOG; COG2197; Bacteria. DR eggNOG; COG3903; Bacteria. DR HOGENOM; CLU_004665_5_3_11; -. DR Proteomes; UP000008710; Chromosome. DR GO; GO:0043531; F:ADP binding; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd06170; LuxR_C_like; 1. DR CDD; cd14014; STKc_PknB_like; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR002182; NB-ARC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR000792; Tscrpt_reg_LuxR_C. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1. DR PANTHER; PTHR47691; REGULATOR-RELATED; 1. DR Pfam; PF00196; GerE; 1. DR Pfam; PF00931; NB-ARC; 1. DR Pfam; PF00069; Pkinase; 1. DR Pfam; PF13424; TPR_12; 1. DR PRINTS; PR00364; DISEASERSIST. DR PRINTS; PR00038; HTHLUXR. DR SMART; SM00421; HTH_LUXR; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR SUPFAM; SSF48452; TPR-like; 1. DR PROSITE; PS50043; HTH_LUXR_2; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Kinase {ECO:0000313|EMBL:ABG94822.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000008710}; KW Transferase {ECO:0000313|EMBL:ABG94822.1}. FT DOMAIN 1..239 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT DOMAIN 968..1033 FT /note="HTH luxR-type" FT /evidence="ECO:0000259|PROSITE:PS50043" FT REGION 250..275 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 255..271 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1035 AA; 112488 MW; 922A35D4C58F3BB8 CRC64; MKVLTVELDE ENRARFFREQ RAMGRLTGHP NIVNILQVGA TDSGLPYIVM PYHPQDSLEA RVRTRGPLPL DQVLRLGVKM AGAVESAHRL GILHRDVKPA NILLTDYGEP ELADFGIAHI SGGFETATGA VTGSPAYTAP EVLGGEPPSP AADVYGLGAT LFSAFTGHAA FERRSGEQVV AQFLRITTQE VPDLRERGLP DDVSAVIAHA MSREPGQRPA TAADFGEQLR GLQRAHGFPV DEMALRAEAD ARGNGEQPTS RSGQGPPAHS TLGATGSLPL ELTSFVGRRH ELTEAKNLLT GSRLVTLTGI GGVGKTRLAI RIASAVQREY SDGVRLVELG ELRDAVSLVD SIAGALGVRD HSTRPLRDVL IEFLAPREVL LVLDNCEHMV DAVAELAGPL LRVSPRLRIL ATSREPLGIG GEAVLRVPPL ALPDPERKPS LRGLPKYDAV TLFTERAAAV PGFVLTEENA ATVAGICHRL DGLPLPIELA AARLRAMSPE QILGRLTDRY ALLTRGSRGA PTRQQTLRLC IDWSFELCTA GEQLLWGRVA VFAGSVELDA AEQVCGEGLD PGELLDTLTS LVEKSILIRE EHGSVVRFRM LETLREYGYE KLEQTGEAVA LRRRHRDWYE ALALDAEAEW ISARQLEWIG RLKREHANLR EALEFSVDDD PAAGLRIAVA LFLFWSSQGL YNEGRRWYDQ LLARQSGPPT LDSIKGLYSH TVMAFAQGDL QAATALVEEA RTLTAHTSDP LLRAYVDCAD GMLALYSGDL ARACSKLEIA LAEFTERGDH MLQVAILYPL GLAHGLSGRT DQAIECHERA LAITEAYGET MYRSHSLWAL GIAVWKQGDA RRSVQLIEQS LKLTKQVRSP RVAAGCLEAL AWISFEGRDA LRAAVLMGAA DGLARSIGST AIIHSNLIRY QQEFAEKARK EVGDKAFGAA HHKGEQLGFD AAIAYALHEQ PSATSTPTAD ASTRLTKRER QVADLIAEGL TNQAIADRLV ISPRTAQGHV EHILAKLGFT SRTQVAAWVV ERAHD //