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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei719 – 7191ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-3619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RHA1_ro03622
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
ProteomesiUP000008710 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligasePRO_0000334804Add
BLAST

Proteomic databases

PRIDEiQ0SAL1.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro03622.

Structurei

3D structure databases

ProteinModelPortaliQ0SAL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionAdd
BLAST
Motifi716 – 7205"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SAL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEHVQPANP SDATPQHRYT AELAGQIEQR WQDRWSEEGT FNAPNPVGPL
60 70 80 90 100
AGDVPADKLF VQDMFPYPSG TGLHVGHPLG YIATDVFARY HRMQGHNVLH
110 120 130 140 150
TLGYDAFGLP AEQYAVQTGT HPRTTTEANI VNMKRQLRRL GLGHDERRTF
160 170 180 190 200
ATTDTDFYHW TQWIFLQIHD AWFDKEAGKA RRISELEAEF VSGARSLEDG
210 220 230 240 250
REWASLSVSE KEAVLDSYRL VYHSDSMVNW CPGLGTVLAN EEVTADGRSD
260 270 280 290 300
RGNFPVFRKH LQQWMMRITA YSDRLVDDLE YLDWPEKVKT MQRNWIGRSH
310 320 330 340 350
GAQVKFQADG HEIEVFTTRP DTLFGATYVT LAPEHELVDD IVAAEWPRGV
360 370 380 390 400
DSRWTGGAAT PAEAVAAYRK SIAAKSDLER QEYKEKTGVF LGTYAVNPVN
410 420 430 440 450
GHKLPVFIAD YVLTGYGTGA IMAVPGHDHR DYEFATEFGL DIVEVISGGD
460 470 480 490 500
LTKDAYTGDG TIVNSDFLNG MSVADAKKAI TERLEADGTG KGTIQYKLRD
510 520 530 540 550
WLFARQRYWG EPFPIVYDAE GNAHALPESS LPVELPEVED YAPVSFDPDD
560 570 580 590 600
ASSEPSPPLA KAVDWVNVEL DLGDGLQTYR RDTNVMPQWA GSSWYQLRYI
610 620 630 640 650
DPTNPDVFCD KENERYWTGP RPEIHGPNDP GGVDLYVGGV EHAVLHLLYS
660 670 680 690 700
RFWHKVLFDL GYVSSSEPYR RLYNQGYIQA YAYTDARGVY VPADEVEEKD
710 720 730 740 750
GKFFHQGVEV NREYGKMGKS LKNSVSPDEI CEEYGADTLR VYEMSMGPLD
760 770 780 790 800
TSRPWATKDV VGAQRFLQRA WRVVVDEESG ALRVTDDAPA EDTLRALNKA
810 820 830 840 850
IAGVSEDYTA LRDNTAAAKL IEYTNHLTKA YPGGAPRSVV EPLVLMLAPL
860 870 880 890 900
APHLAEELWS RLGHEKSLAH GPFPVAEEKW LVEDTVEYPI QVNGKVRSRV
910 920 930 940
TVAADAPREE IEKIALADDK IVALLDGQDP RKVIVVPGKM VNIVR
Length:945
Mass (Da):105,846
Last modified:September 5, 2006 - v1
Checksum:iF7F47175CDDBCE1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1.
RefSeqiWP_011596228.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG95425; ABG95425; RHA1_ro03622.
GeneIDi4221173.
KEGGirha:RHA1_ro03622.
PATRICi23206099. VBIRhoJos26306_3650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1.
RefSeqiWP_011596228.1. NC_008268.1.

3D structure databases

ProteinModelPortaliQ0SAL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi101510.RHA1_ro03622.

Proteomic databases

PRIDEiQ0SAL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG95425; ABG95425; RHA1_ro03622.
GeneIDi4221173.
KEGGirha:RHA1_ro03622.
PATRICi23206099. VBIRhoJos26306_3650.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-3619-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiSYL_RHOJR
AccessioniPrimary (citable) accession number: Q0SAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.