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Q0SAL1 (SYL_RHOSR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RHA1_ro03622
OrganismRhodococcus sp. (strain RHA1) [Complete proteome] [HAMAP]
Taxonomic identifier101510 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 945945Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334804

Regions

Motif66 – 7712"HIGH" region HAMAP-Rule MF_00049
Motif716 – 7205"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7191ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0SAL1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: F7F47175CDDBCE1C

FASTA945105,846
        10         20         30         40         50         60 
MTEHVQPANP SDATPQHRYT AELAGQIEQR WQDRWSEEGT FNAPNPVGPL AGDVPADKLF 

        70         80         90        100        110        120 
VQDMFPYPSG TGLHVGHPLG YIATDVFARY HRMQGHNVLH TLGYDAFGLP AEQYAVQTGT 

       130        140        150        160        170        180 
HPRTTTEANI VNMKRQLRRL GLGHDERRTF ATTDTDFYHW TQWIFLQIHD AWFDKEAGKA 

       190        200        210        220        230        240 
RRISELEAEF VSGARSLEDG REWASLSVSE KEAVLDSYRL VYHSDSMVNW CPGLGTVLAN 

       250        260        270        280        290        300 
EEVTADGRSD RGNFPVFRKH LQQWMMRITA YSDRLVDDLE YLDWPEKVKT MQRNWIGRSH 

       310        320        330        340        350        360 
GAQVKFQADG HEIEVFTTRP DTLFGATYVT LAPEHELVDD IVAAEWPRGV DSRWTGGAAT 

       370        380        390        400        410        420 
PAEAVAAYRK SIAAKSDLER QEYKEKTGVF LGTYAVNPVN GHKLPVFIAD YVLTGYGTGA 

       430        440        450        460        470        480 
IMAVPGHDHR DYEFATEFGL DIVEVISGGD LTKDAYTGDG TIVNSDFLNG MSVADAKKAI 

       490        500        510        520        530        540 
TERLEADGTG KGTIQYKLRD WLFARQRYWG EPFPIVYDAE GNAHALPESS LPVELPEVED 

       550        560        570        580        590        600 
YAPVSFDPDD ASSEPSPPLA KAVDWVNVEL DLGDGLQTYR RDTNVMPQWA GSSWYQLRYI 

       610        620        630        640        650        660 
DPTNPDVFCD KENERYWTGP RPEIHGPNDP GGVDLYVGGV EHAVLHLLYS RFWHKVLFDL 

       670        680        690        700        710        720 
GYVSSSEPYR RLYNQGYIQA YAYTDARGVY VPADEVEEKD GKFFHQGVEV NREYGKMGKS 

       730        740        750        760        770        780 
LKNSVSPDEI CEEYGADTLR VYEMSMGPLD TSRPWATKDV VGAQRFLQRA WRVVVDEESG 

       790        800        810        820        830        840 
ALRVTDDAPA EDTLRALNKA IAGVSEDYTA LRDNTAAAKL IEYTNHLTKA YPGGAPRSVV 

       850        860        870        880        890        900 
EPLVLMLAPL APHLAEELWS RLGHEKSLAH GPFPVAEEKW LVEDTVEYPI QVNGKVRSRV 

       910        920        930        940 
TVAADAPREE IEKIALADDK IVALLDGQDP RKVIVVPGKM VNIVR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000431 Genomic DNA. Translation: ABG95425.1.
RefSeqYP_703583.1. NC_008268.1.

3D structure databases

ProteinModelPortalQ0SAL1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING101510.RHA1_ro03622.

Proteomic databases

PRIDEQ0SAL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG95425; ABG95425; RHA1_ro03622.
GeneID4221173.
KEGGrha:RHA1_ro03622.
PATRIC23206099. VBIRhoJos26306_3650.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycRJOS101510:GJJ1-3619-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_RHOSR
AccessionPrimary (citable) accession number: Q0SAL1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries