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Q0SAL1

- SYL_RHOJR

UniProt

Q0SAL1 - SYL_RHOJR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodococcus jostii (strain RHA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei719 – 7191ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-3619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RHA1_ro03622
OrganismiRhodococcus jostii (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligasePRO_0000334804Add
BLAST

Proteomic databases

PRIDEiQ0SAL1.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro03622.

Structurei

3D structure databases

ProteinModelPortaliQ0SAL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionAdd
BLAST
Motifi716 – 7205"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SAL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEHVQPANP SDATPQHRYT AELAGQIEQR WQDRWSEEGT FNAPNPVGPL
60 70 80 90 100
AGDVPADKLF VQDMFPYPSG TGLHVGHPLG YIATDVFARY HRMQGHNVLH
110 120 130 140 150
TLGYDAFGLP AEQYAVQTGT HPRTTTEANI VNMKRQLRRL GLGHDERRTF
160 170 180 190 200
ATTDTDFYHW TQWIFLQIHD AWFDKEAGKA RRISELEAEF VSGARSLEDG
210 220 230 240 250
REWASLSVSE KEAVLDSYRL VYHSDSMVNW CPGLGTVLAN EEVTADGRSD
260 270 280 290 300
RGNFPVFRKH LQQWMMRITA YSDRLVDDLE YLDWPEKVKT MQRNWIGRSH
310 320 330 340 350
GAQVKFQADG HEIEVFTTRP DTLFGATYVT LAPEHELVDD IVAAEWPRGV
360 370 380 390 400
DSRWTGGAAT PAEAVAAYRK SIAAKSDLER QEYKEKTGVF LGTYAVNPVN
410 420 430 440 450
GHKLPVFIAD YVLTGYGTGA IMAVPGHDHR DYEFATEFGL DIVEVISGGD
460 470 480 490 500
LTKDAYTGDG TIVNSDFLNG MSVADAKKAI TERLEADGTG KGTIQYKLRD
510 520 530 540 550
WLFARQRYWG EPFPIVYDAE GNAHALPESS LPVELPEVED YAPVSFDPDD
560 570 580 590 600
ASSEPSPPLA KAVDWVNVEL DLGDGLQTYR RDTNVMPQWA GSSWYQLRYI
610 620 630 640 650
DPTNPDVFCD KENERYWTGP RPEIHGPNDP GGVDLYVGGV EHAVLHLLYS
660 670 680 690 700
RFWHKVLFDL GYVSSSEPYR RLYNQGYIQA YAYTDARGVY VPADEVEEKD
710 720 730 740 750
GKFFHQGVEV NREYGKMGKS LKNSVSPDEI CEEYGADTLR VYEMSMGPLD
760 770 780 790 800
TSRPWATKDV VGAQRFLQRA WRVVVDEESG ALRVTDDAPA EDTLRALNKA
810 820 830 840 850
IAGVSEDYTA LRDNTAAAKL IEYTNHLTKA YPGGAPRSVV EPLVLMLAPL
860 870 880 890 900
APHLAEELWS RLGHEKSLAH GPFPVAEEKW LVEDTVEYPI QVNGKVRSRV
910 920 930 940
TVAADAPREE IEKIALADDK IVALLDGQDP RKVIVVPGKM VNIVR
Length:945
Mass (Da):105,846
Last modified:September 5, 2006 - v1
Checksum:iF7F47175CDDBCE1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1.
RefSeqiYP_703583.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG95425; ABG95425; RHA1_ro03622.
GeneIDi4221173.
KEGGirha:RHA1_ro03622.
PATRICi23206099. VBIRhoJos26306_3650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1 .
RefSeqi YP_703583.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0SAL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro03622.

Proteomic databases

PRIDEi Q0SAL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG95425 ; ABG95425 ; RHA1_ro03622 .
GeneIDi 4221173.
KEGGi rha:RHA1_ro03622.
PATRICi 23206099. VBIRhoJos26306_3650.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-3619-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiSYL_RHOJR
AccessioniPrimary (citable) accession number: Q0SAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3