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Q0SAL1

- SYL_RHOSR

UniProt

Q0SAL1 - SYL_RHOSR

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Protein
Leucine--tRNA ligase
Gene
leuS, RHA1_ro03622
Organism
Rhodococcus sp. (strain RHA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei719 – 7191ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRJOS101510:GJJ1-3619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RHA1_ro03622
OrganismiRhodococcus sp. (strain RHA1)
Taxonomic identifieri101510 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000008710: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligaseUniRule annotation
PRO_0000334804Add
BLAST

Proteomic databases

PRIDEiQ0SAL1.

Interactioni

Protein-protein interaction databases

STRINGi101510.RHA1_ro03622.

Structurei

3D structure databases

ProteinModelPortaliQ0SAL1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionUniRule annotation
Add
BLAST
Motifi716 – 7205"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0SAL1-1 [UniParc]FASTAAdd to Basket

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MTEHVQPANP SDATPQHRYT AELAGQIEQR WQDRWSEEGT FNAPNPVGPL    50
AGDVPADKLF VQDMFPYPSG TGLHVGHPLG YIATDVFARY HRMQGHNVLH 100
TLGYDAFGLP AEQYAVQTGT HPRTTTEANI VNMKRQLRRL GLGHDERRTF 150
ATTDTDFYHW TQWIFLQIHD AWFDKEAGKA RRISELEAEF VSGARSLEDG 200
REWASLSVSE KEAVLDSYRL VYHSDSMVNW CPGLGTVLAN EEVTADGRSD 250
RGNFPVFRKH LQQWMMRITA YSDRLVDDLE YLDWPEKVKT MQRNWIGRSH 300
GAQVKFQADG HEIEVFTTRP DTLFGATYVT LAPEHELVDD IVAAEWPRGV 350
DSRWTGGAAT PAEAVAAYRK SIAAKSDLER QEYKEKTGVF LGTYAVNPVN 400
GHKLPVFIAD YVLTGYGTGA IMAVPGHDHR DYEFATEFGL DIVEVISGGD 450
LTKDAYTGDG TIVNSDFLNG MSVADAKKAI TERLEADGTG KGTIQYKLRD 500
WLFARQRYWG EPFPIVYDAE GNAHALPESS LPVELPEVED YAPVSFDPDD 550
ASSEPSPPLA KAVDWVNVEL DLGDGLQTYR RDTNVMPQWA GSSWYQLRYI 600
DPTNPDVFCD KENERYWTGP RPEIHGPNDP GGVDLYVGGV EHAVLHLLYS 650
RFWHKVLFDL GYVSSSEPYR RLYNQGYIQA YAYTDARGVY VPADEVEEKD 700
GKFFHQGVEV NREYGKMGKS LKNSVSPDEI CEEYGADTLR VYEMSMGPLD 750
TSRPWATKDV VGAQRFLQRA WRVVVDEESG ALRVTDDAPA EDTLRALNKA 800
IAGVSEDYTA LRDNTAAAKL IEYTNHLTKA YPGGAPRSVV EPLVLMLAPL 850
APHLAEELWS RLGHEKSLAH GPFPVAEEKW LVEDTVEYPI QVNGKVRSRV 900
TVAADAPREE IEKIALADDK IVALLDGQDP RKVIVVPGKM VNIVR 945
Length:945
Mass (Da):105,846
Last modified:September 5, 2006 - v1
Checksum:iF7F47175CDDBCE1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1.
RefSeqiYP_703583.1. NC_008268.1.

Genome annotation databases

EnsemblBacteriaiABG95425; ABG95425; RHA1_ro03622.
GeneIDi4221173.
KEGGirha:RHA1_ro03622.
PATRICi23206099. VBIRhoJos26306_3650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000431 Genomic DNA. Translation: ABG95425.1 .
RefSeqi YP_703583.1. NC_008268.1.

3D structure databases

ProteinModelPortali Q0SAL1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 101510.RHA1_ro03622.

Proteomic databases

PRIDEi Q0SAL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG95425 ; ABG95425 ; RHA1_ro03622 .
GeneIDi 4221173.
KEGGi rha:RHA1_ro03622.
PATRICi 23206099. VBIRhoJos26306_3650.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RJOS101510:GJJ1-3619-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RHA1.

Entry informationi

Entry nameiSYL_RHOSR
AccessioniPrimary (citable) accession number: Q0SAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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